2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation Apoptosis
  3. p38 MAPK ERK JNK Interleukin Related TNF Receptor
  4. Sugiol

Sugiol  (Synonyms: (+)-Sugiol; 10-Deoxoxanthoperol)

目录号: HY-N1195
产品使用指南

摩尔计算器

Sugiol 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。

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Sugiol Chemical Structure

Sugiol Chemical Structure

CAS No. : 511-05-7

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Customer Review

Sugiol 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].

IC50 & Target[1]

ERK1

 

ERK2

 

p38 MAPK

 

JNK1

 

JNK2

 

IL-1β

 

体外研究
(In Vitro)

Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。
Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sugiol 相关抗体:

Western Blot Analysis[1]

Cell Line: J774A.1 macrophages cells stimulated with LPS
Concentration: 5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time: 30 min
Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
分子量

300.44

Formula

C20H28O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sugiol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sugiol511-05-7(+)-Sugiol 10-Deoxoxanthoperolp38 MAPKERKJNKInterleukin RelatedTNF ReceptorExtracellular signal regulated kinasesc-Jun N-terminal kinaseILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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