2. Immunology/Inflammation GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. PGE synthase Prostaglandin Receptor β-catenin STAT c-Myc
  4. SZ0232

SZ0232 是一种微粒体前列腺素 E 合成酶-2 (mPGES-2) 抑制剂。SZ0232通过抑制 mPGES-2 活性、下调 PGE2-EP4 信号、进而阻断 β-catenin/STAT3/c-Myc 增殖通路。SZ0232 抑制囊肿上皮细胞异常增殖，并在体内外模型中显著抑制了囊肿生长。SZ0232 可用于研究常染色体显性多囊肾病 (ADPKD)。

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SZ0232

SZ0232 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

SZ0232 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SZ0232 is a microsomal prostaglandin E synthase-2 (mPGES-2) inhibitor. SZ0232 inhibits the activity of mPGES-2, downregulates the PGE2-EP4 signal, and thereby blocks the β-catenin/STAT3/c-Myc proliferation pathway. SZ0232 inhibits the abnormal proliferation of cyst epithelial cells and significantly inhibits cyst growth in both in vitro and in vivo models. SZ0232 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD)[1].

IC50 & Target[1]

EP4

 

STAT3

 

分子量

520.56

Formula

C22H28N6O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SZ0232 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SZ0232SZ 0232SZ-0232PGE synthaseProstaglandin Receptorβ-cateninSTATc-MycProstaglandin E synthaseBeta cateninMycADPKDmPGES-2PGE2proliferationβ-catenin/STAT3Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179041
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