1. Immunology/Inflammation
  2. MyD88
  3. T6167923

T6167923 

目录号: HY-19744
产品使用指南

T6167923 是一种有效的 MyD88 Toll / IL1受体 (TIR) 结构域二聚化抑制剂,破坏了 MYD88 的同二聚体形成。T6167923 可与原始靶标和 Mal,TRIF,TRAM 的 TIR 结构域结合良好。T6167923 抑制 NF-κB 驱动的 葡萄球菌肠毒素AP (SEAP) 活性,并且改善抗炎活性,对 IFN-γ,IL-1β,IL-6 和 TNF-α 的 IC50 分别为 2.7  μM,2.9 μM,2.66 μM 和 2.66 μM。

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T6167923 Chemical Structure

T6167923 Chemical Structure

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Description

T6167923 is a potent MyD88 Toll/IL1 receptor (TIR) domain dimerization inhibitor, which disrupts MyD88 homodimeric formation. T6167923 binds well to the original target and the TIR domains of Mal, TRIF and TRAM. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50 of 2.7  μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively [1][2].

IC50 & Target

MyD88[1]

Molecular Weight

458.39

Formula

C₁₇H₂₀BrN₃O₃S₂

SMILES

BrC1=CC(S(=O)(N2CCN(C(N[C@H](C3=CC=CS3)C)=O)CC2)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
T6167923
目录号:
HY-19744
需求量:

T6167923

Cat. No.: HY-19744