2. Immunology/Inflammation
  3. Interleukin Related
  4. Tagraxofusp

Tagraxofusp  (Synonyms: SL-401)

目录号: HY-P99536

摩尔计算器

Tagraxofusp (SL-401) 是一种有效的 IL-3 受体抑制剂，可抑制多发性骨髓瘤 (MM) 骨髓 (BM) 微环境中浆细胞样树突状细胞 (pDCs) 的生长。Tagraxofusp 与 Bortezomib (HY-10227)、Pomalidomide (HY-10984) 有协同抑制多发性骨髓瘤的作用。

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Tagraxofusp Chemical Structure

Tagraxofusp Chemical Structure

CAS No. : 2055491-00-2

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Tagraxofusp 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tagraxofusp (SL-401) is a potent IL-3 receptor inhibitor to inhibits plasmacytoid dendritic cells (pDCs) growth in multiple myeloma (MM) bone marrow (BM) microenvironment. Tagraxofusp has synergistic effect with Bortezomib (HY-10227) and Pomalidomide (HY-10984) to suppress multiple myeloma (MM)[1].

IC50 & Target[1]

IL-3

 

体外研究
(In Vitro)

Tagraxofusp (0-1367 pM; 72 小时) 抑制 pDCs的活力，以及pDCs诱导的MM细胞增殖[1]。
Tagraxofusp (0-136.7 pM; 2-3 周) 抑制破骨细胞形成和骨吸收，以及稳定成骨细胞形成[1]。
Tagraxofusp (0-13.67 nM; 48 小时)在 MM 中靶向肿瘤启动干细胞样细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tagraxofusp 相关抗体:

Cell Viability Assay[1]

Cell Line: Cancer stem-like cells in MM
Concentration: 0 nM, 0.013 nM, 0.13 nM, 1.3 nM, 13.67 nM
Incubation Time: 48 hours
Result: Inhibits cancer stem-like cells with s of 30 pM (pDCs), 50 nM (MM-SP-Oct4 cells), 75 pM (RPMI-8226-Oct4 cells), 350 pM (MM-SP cells), and 1367 pM (RPMI-8226 cells), respectively.
体内研究
(In Vivo)

Tagraxofusp (12-50 μg/kg; 静脉注射; 每周 5 次, 共 3 周) 阻断 pDC 诱导的肿瘤生长，延长带有皮下INA-6 多发性骨髓瘤的 SCID-hu 小鼠的生存期[1]。
Tagraxofusp (16 μg/kg; i.v.; 静脉注射; 每周 5 次, 共 1 周) 可增强 2.5 mg/kg Pomalidomide 在皮下多发性骨髓瘤 CB-17 小鼠中的抗多发性骨髓瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-hu mice with INA-6 MM cells[1]
Dosage: 12 μg/kg, 16 μg/kg, 25 μg/kg and 50 μg/kg
Administration: Intravenous injection; for 5 consecutive days each week for 3 weeks
Result: Blocked pDC-induced tumor growth and prolonged mice survival at 12 μg/kg.
Showed well tolerance at 16 μg/kg, while higher doses resulted in body weight decrease and toxicity.
Animal Model: CB-17 mice with subcutaneous MM xenograft model[1]
Dosage: 16 μg/kg; with or without 2.5 mg/kg Pomalidomide (p.o.; 4 consecutive days weekly for 2 weeks)
Administration: Intravenous injection; dose at 5 consecutive days for first week
Result: Enhanced the anti-MM activity of proteasome inhibitor and immunomodulatory drug pomalidomide.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tagraxofusp 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Tagraxofusp2055491-00-2SL-401SL401SL 401Interleukin RelatedILInhibitorinhibitorinhibit

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