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TC-E 5001 是一种 Wnt 通路抑制剂,通过新型腺苷袋结合抑制端锚聚合酶 1/2 (TNKS1/2),Kds 值分别为 79 和 28 nM。TC-E 5001 还抑制 Axin2STFIC50 值分别为 0.709 μM 和 0.215 μM。

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TC-E 5001 Chemical Structure

TC-E 5001 Chemical Structure

CAS No. : 865565-29-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2].

IC50 & Target[1]

TNKS1

79 nM (Ki)

TNKS2

28 nM (Ki)

体外研究
(In Vitro)

TC-E 5001 inhibits TNKS2, with an IC50 of 33 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

409.46

Formula

C20H19N5O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

TC-E 5001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TC-E 5001
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HY-108516
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