2. TGF-beta/Smad
  3. TGF-β Receptor
  4. THRX-144644

THRX-144644 是一种肺限制性 ALK5 抑制剂，其 IC50 值为 0.14 nM。THRX-144644 避免了与 TGFβ 途径抑制相关的全身毒性。

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THRX-144644 Chemical Structure

THRX-144644 Chemical Structure

CAS No. : 2442519-59-5

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THRX-144644 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition[1].

IC50 & Target[1]

ALK5

0.14 nM (IC50)

体外研究
(In Vitro)

THRX-144644 (1-10000 nM; 1 h) inhibits ALK5 with an IC50 value of 23 nM in human BEAS2B cell line.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

THRX-144644 相关抗体:
体内研究
(In Vivo)

THRX-144644 (2-60 mg/kg; Inhalation: nebulizer, daily, for 14 days) is a Lung-selective inhibitor and targets to the lungs in Sprague Dawley rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[1]
Dosage: 2, 10, and 60 mg/kg
Administration: Inhalation: nebulizer, daily, for 14 days
Result: Had the L:P ratio (AUC) was 0.44.
Had lung-to-plasma ratios ranged from 100- to 1200-fold in rats across dose level.
Had lung trough (24 h) concentrations in rats ranged from 3- to 17-fold above the PCLS IC50 across tolerated doses.
分子量

512.00

Formula

C26H28ClF2N7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

THRX-144644 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THRX-1446442442519-59-5THRX144644THRX 144644TGF-β ReceptorTransforming growth factor beta receptorslung-selectiveTGFβBEAS2B cell linesystemic toxicitiesInhibitorinhibitorinhibit

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产品名称：
THRX-144644
目录号：
HY-150169
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