2. Apoptosis
  3. Apoptosis
  4. Triphen diol

Triphen diol 是一种苯酚二醇衍生物，对胰腺癌和胆管癌具有优异的抗癌活性，可以通过 caspase 介导的和 caspase 不依赖的两种机制诱导胰腺细胞凋亡(apoptosis)。

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Triphen diol Chemical Structure

Triphen diol Chemical Structure

CAS No. : 1213777-80-0

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Triphen diol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent[1].
体外研究
(In Vitro)

Triphen diol (0-10 μM, 48-120 h)可抑制胰腺细胞增殖并诱导细胞凋亡，作用于 HPAC 和 PANC-1 细胞的 IC50值为 8 μM，作用于 MIAPaCa-2 细胞的 IC50 值为 0.8 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Triphen diol 相关抗体:

Apoptosis Analysis[1]

Cell Line: Human pancreatic cell lines HPAC, MIAPaCa-2, and PANC-1
Concentration: 10 μM
Incubation Time: 48 h
Result: Induced caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells, 60% of the cells were in the early stage of apoptosis, and 30% of the cells were in the late stage of apoptosis.
Reduced Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
体内研究
(In Vivo)

Triphen diol(50 mg/kg, oral gavage, daily, 15 days) 在雄性移植了 MIAPaCa2 细胞系的 Balb/c 裸鼠中，可以显著抑制肿瘤的增殖，并且可以与吉西他滨联用显示更好的疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

348.39

Formula

C22H20O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Triphen diol 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triphen diol1213777-80-0ApoptosisanticancerpancreaticcholangiocarcinomaapoptosiscaspaseInhibitorinhibitorinhibit

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