2. Stem Cell/Wnt
  3. β-catenin Wnt
  4. UU-T02

UU-T02 是一种新型强效的 β-Catenin/T-cell factor 蛋白互作的选择性小分子抑制剂 (β-catenin/Tcf PPI)，Ki 为 1.36 μM。UU-T02 抑制典型 Wnt 信号的传导和结直肠癌细胞的生长。

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UU-T02 Chemical Structure

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

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UU-T02 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].

IC50 & Target

Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].
体外研究
(In Vitro)

UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM，respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UU-T02 相关抗体:
分子量

665.09

Formula

C33H33ClN4O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UU-T02 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UU-T021500080-17-0β-cateninWntBeta cateninsignalingcolorectalcancer cellFP assayAlphaScreen assayInhibitorinhibitorinhibit

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目录号：
HY-117233
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