1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. Vorapaxar sulfate

Vorapaxar sulfate (Synonyms: SCH 530348 sulfate)

目录号: HY-10119A
产品使用指南

Vorapaxar sulfate (SCH 530348 sulfate),抗血小板药物,是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体 (PAR-1) 拮抗剂,Ki 值为 8.1 nM。Vorapaxar sulfate剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集。

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Vorapaxar sulfate Chemical Structure

Vorapaxar sulfate Chemical Structure

CAS No. : 705260-08-8

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Vorapaxar sulfate 的其他形式现货产品:

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Description

Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner[1].

IC50 & Target

Ki: 8.1 nM (PAR-1)[1]

In Vitro

Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM[1].

Clinical Trial
Molecular Weight

590.66

Formula

C₂₉H₃₅FN₂O₈S

CAS No.

705260-08-8

SMILES

O=C(O[C@@H]1C)[C@@]2([H])[C@]1([H])[C@@H](/C=C/C3=NC=C(C=C3)C4=CC=CC(F)=C4)[C@]([C@](C5)([H])C2)([H])CC[C@H]5NC(OCC)=O.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

VorapaxarSCH 530348SCH530348SCH-530348Protease-Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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产品名称:
Vorapaxar sulfate
目录号:
HY-10119A
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