2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor
  4. Xanthine oxidase-IN-6

Xanthine oxidase-IN-6 (Compound 6c) 是一种强效的、具有口服活性的黄嘌呤氧化酶 (XOD) 混合型抑制剂，其 IC50 值为1.37 µM。Xanthine oxidase-IN-6 具有很强的抗高尿酸血症 (anti-hyperuricemia) 和肾保护活性。

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Xanthine oxidase-IN-6 Chemical Structure

Xanthine oxidase-IN-6 Chemical Structure

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Xanthine oxidase-IN-6 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC50 value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity[1].

IC50 & Target

NF-κB

 

TLR4

 

XOD

1.37 μM (IC50)

体外研究
(In Vitro)

Xanthine oxidase-IN-6 (Compound 6c) is a mixed-type XOD inhibitor, preferentially bound to the free enzyme and not the enzyme substrate complex[1].
Xanthine oxidase-IN-6 is stable in simulated gastrointestinal digestion, with hydrolysis half-life more than 4 h[1].
Xanthine oxidase-IN-6 (0-100 µM) exhibits an obvious anti-inflammatory effect by reducing the level of inflammatory factors (TGF-β, TNF-α and IL-1β) in a dose-dependent manner[1].
Xanthine oxidase-IN-6 (0-100 µM, 48 h) inhibits HK-2 cell epithelial mesenchymal transition under high level of uric acid[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthine oxidase-IN-6 相关抗体:

Western Blot Analysis[1]

Cell Line: HK-2 cells
Concentration: 12.5, 25, 50, and 100 µM
Incubation Time: 48 h
Result: Reduced the protein levels of α-SMA and Collagen I in a dose-dependent manner
体内研究
(In Vivo)

Xanthine oxidase-IN-6 (Compound 6c) (0-20 mg/kg; i.g.; once daily for 2 weeks) shows anti-hyperuricemic effects, alleviates kidney damage, and inhibits XOD activity in a dose-dependent manner[1].
Xanthine oxidase-IN-6 (0-20 mg/kg; i.g.; once daily for 2 weeks) effectively reduces renal fibrosis and inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (male, weight 20 ± 2 g). Hyperuricemic mouse model established by administering 0.5% CMC-Na (10 mL/kg), adenine (200 mg/kg) and potassium oxonate (500 mg/kg); oral gavage once daily for 2 or 4 weeks[1].
Dosage: 5, 10 and 20 mg/kg
Administration: Gavage, once daily for 2 weeks
Result: Effectively decreased the levels of SUA, Cr, and BUN, effectively inhibited XOD activity and urate accumulation in a dose-dependent manner. Remarkedly improved the morphologic lesions with less fibrosis in the interstitium. Reduced the production of multiple cytokines (TNF-α, IL-8, and IL-1β). Reduced the expression of α-SMA, collagen I, TLR4, NF-κB, IκBα and TNF-α.
分子量

650.58

Formula

C29H34N2O15
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Xanthine oxidase-IN-6 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthine oxidase-IN-6Xanthine OxidaseNF-κBToll-like Receptor (TLR)TNF ReceptorXONuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRTGF-βTNF-αIL-1βHK-2Collagen Iα-SMAInhibitorinhibitorinhibit

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