2. NF-κB Metabolic Enzyme/Protease
  3. NF-κB Endogenous Metabolite
  4. Cyclo(his-pro)

Cyclo(his-pro)  (Synonyms: Cyclo(histidyl-proline); Histidylproline diketopiperazine)

目录号: HY-101402
产品使用指南

摩尔计算器

Cyclo(his-pro) (Cyclo(histidyl-proline)) 是一种具有口服活性的，结构上与促甲状腺激素释放激素相关的环状二肽。Cyclo(his-pro) 可以抑制 NF-κB 核积累。Cyclo(his-pro) 可以穿越脑血屏障并影响多种炎症和应激反应。

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Cyclo(his-pro) Chemical Structure

Cyclo(his-pro) Chemical Structure

CAS No. : 53109-32-3

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
10 mM * 1 mL in Water ￥990
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1 mg ￥500
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5 mg ￥900
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10 mg ￥1500
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25 mg ￥2900
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50 mg ￥5400
询问价格 & 货期
100 mg ￥9700
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* Please select Quantity before adding items.

Cyclo(his-pro) 的其他形式现货产品:

Customer Review

Other Forms of Cyclo(his-pro):

Cyclo(his-pro) 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].

IC50 & Target

NF-κB

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors[2].
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release[2].
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(his-pro) 相关抗体:

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 50 μM
Incubation Time: 1, 2, 4, 8, 24, 48 hours
Result: Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation.
体内研究
(In Vivo)

Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect[2].
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sixty two/three month-old male C57BL/6 mice (25-30 g)[2]
Dosage: 1.8 mg/ear
Administration: Topical application on the right ear; 30 min prior to TPA
Result: Reduced TPA-induced ear oedema.
分子量

234.25

Formula

C11H14N4O2
CAS 号
性状

固体

颜色

Light yellow to yellow

Sequence Shortening

Cyclo(HP)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 30 mg/mL (128.07 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.2689 mL 21.3447 mL 42.6894 mL
5 mM 0.8538 mL 4.2689 mL 8.5379 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Cyclo(his-pro) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.2689 mL 21.3447 mL 42.6894 mL 106.7236 mL
5 mM 0.8538 mL 4.2689 mL 8.5379 mL 21.3447 mL
10 mM 0.4269 mL 2.1345 mL 4.2689 mL 10.6724 mL
15 mM 0.2846 mL 1.4230 mL 2.8460 mL 7.1149 mL
20 mM 0.2134 mL 1.0672 mL 2.1345 mL 5.3362 mL
25 mM 0.1708 mL 0.8538 mL 1.7076 mL 4.2689 mL
30 mM 0.1423 mL 0.7115 mL 1.4230 mL 3.5575 mL
40 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6681 mL
50 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1345 mL
60 mM 0.0711 mL 0.3557 mL 0.7115 mL 1.7787 mL
80 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
100 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(his-pro)53109-32-3Cyclo(histidyl-proline) Histidylproline diketopiperazineNF-κBEndogenous MetaboliteNuclear factor-κBNuclear factor-kappaBorallyactivecyclicdipeptidetyreotropin-releasinghormonebrain-blood-barrierinflammatorystressresponsesInhibitorinhibitorinhibit

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