2. Anti-infection
  3. Bacterial Antibiotic
  4. Delafloxacin meglumine

Delafloxacin meglumine  (Synonyms: 德拉沙星葡甲胺; ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine)

目录号: HY-14814A 纯度: 99.87%
COA 产品使用指南

摩尔计算器

Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) 是一种广谱氟喹诺酮类抗生素。Delafloxacin 具有广泛的活性，对耐药性的金黄色葡萄球菌，肺炎链球菌和肺炎克雷伯菌都有效。

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Delafloxacin meglumine Chemical Structure

Delafloxacin meglumine Chemical Structure

CAS No. : 352458-37-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550
In-stock
5 mg ￥312
In-stock
10 mg ￥500
In-stock
50 mg ￥2000
In-stock
100 mg ￥3500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Delafloxacin meglumine:

Delafloxacin meglumine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].

IC50 & Target

Quinolone

 

体内研究
(In Vivo)

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with a neutropenic murine lung infection model (four S. aureus, four S. pneumoniae, and four K. pneumoniae strains)[1]
Dosage: The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration: 0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result: Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively.
Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively.
Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.
Animal Model: Neutropenic mice[1]
Dosage: 2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration: Subcutaneous injection; 24 h
Result: The maximum drug concentrations (Cmax) concentrations ranged from 2 to 71 mg/L. AUC0-∞ values ranged from 2.8 to 152 mg•h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t1/2) ranged from 0.7 to 1 h.
Clinical Trial
分子量

635.97

Formula

C25H29ClF3N5O9
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

德拉沙星葡甲胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (78.62 mM; 超声助溶)

DMSO 中的溶解度 : ≥ 6.4 mg/mL (10.06 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5724 mL 7.8620 mL 15.7240 mL
5 mM 0.3145 mL 1.5724 mL 3.1448 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Delafloxacin meglumine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.5724 mL 7.8620 mL 15.7240 mL 39.3100 mL
5 mM 0.3145 mL 1.5724 mL 3.1448 mL 7.8620 mL
10 mM 0.1572 mL 0.7862 mL 1.5724 mL 3.9310 mL
H2O 15 mM 0.1048 mL 0.5241 mL 1.0483 mL 2.6207 mL
20 mM 0.0786 mL 0.3931 mL 0.7862 mL 1.9655 mL
25 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5724 mL
30 mM 0.0524 mL 0.2621 mL 0.5241 mL 1.3103 mL
40 mM 0.0393 mL 0.1966 mL 0.3931 mL 0.9828 mL
50 mM 0.0314 mL 0.1572 mL 0.3145 mL 0.7862 mL
60 mM 0.0262 mL 0.1310 mL 0.2621 mL 0.6552 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delafloxacin352458-37-8ABT492RX-3341WQ-3034德拉沙星葡甲胺ABT 492ABT-492RX3341RX 3341WQ3034WQ 3034BacterialAntibioticInhibitorinhibitorinhibit

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