1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. SGD-1882

SGD-1882 (Synonyms: PBD dimer)

目录号: HY-101127
产品使用指南

SGD-1882 是一种有细胞毒性的 DNA 小沟交联剂,为 PBD 二聚体,可以作为 ADC 的有效载荷。

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SGD-1882 Chemical Structure

SGD-1882 Chemical Structure

CAS No. : 1222490-34-7

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Description

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

In Vitro

SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2].

Molecular Weight

725.79

Formula

C₄₂H₃₉N₅O₇

CAS No.

1222490-34-7

SMILES

O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SGD-1882PBD dimerSGD1882SGD 1882ADC CytotoxinInhibitorinhibitorinhibit

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产品名称:
SGD-1882
目录号:
HY-101127
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