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Ceranib1 

目录号: HY-103359
产品使用指南

Ceranib1 是一种神经酰胺酶 (ceramidase) 抑制剂。Ceranib1 能抑制细胞神经酰胺酶对外源性神经酰胺类似物的活性,诱导多种神经酰胺物质的积累,降低鞘氨醇和 S1P 水平。Ceranib1 能抑制细胞卵巢癌细胞增殖。

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Ceranib1 Chemical Structure

Ceranib1 Chemical Structure

CAS No. : 328076-61-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ceranib1 is a ceramidase inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells[1].

IC50 & Target

ceramidase[1]

体外研究
(In Vitro)

Ceranib1 produces a dose-dependent decrease in ceramidase activity, with 50% inhibition at 55 and 28 μM in SKOV3 cells[1].
Ceranib1 (24 hours) does not cause significant acute cytotoxicity at concentrations up to at least those used in the ceramidase assay in SKOV3 cells[1].
Ceranib1 prevents the hydrolysis of endogenous ceramide species and reduces intracellular sphingosine and S1P[1].
Ceranib1 (10 nM-10 μM; 72 hours) exhibits antiproliferative activity for SKOV3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SKOV3 cells
Concentration: 10 nM-10 μM (varying concentrations)
Incubation Time: 72 hours
Result: Inhibited cell proliferation with IC50 values of 3.9 ± 0.3 μM.
分子量

395.45

Formula

C26H21NO3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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Ceranib1
目录号:
HY-103359
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