1. PI3K/Akt/mTOR
  2. Akt
  3. AKT Kinase Inhibitor hydrochloride

AKT Kinase Inhibitor hydrochloride 

目录号: HY-10249D 纯度: 99.24%
COA 产品使用指南

AKT Kinase Inhibitor hydrochloride 是一种具有抗肿瘤活性的 Akt 抑制剂。

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AKT Kinase Inhibitor hydrochloride Chemical Structure

AKT Kinase Inhibitor hydrochloride Chemical Structure

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in Water ¥3850
询价
5 mg ¥3500
In-stock
10 mg ¥6000
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of AKT Kinase Inhibitor hydrochloride:

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Top Publications Citing Use of Products

    AKT Kinase Inhibitor hydrochloride purchased from MCE. Usage Cited in: Mediat Inflamm. 2020 Jun 24;2020:3621261.  [Abstract]

    After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

    查看 Akt 亚型特异性产品:

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity[1]. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

    体外研究
    (In Vitro)

    The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    393.83

    Formula

    C16H20ClN7O3

    性状

    固体

    颜色

    Off-white to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 20 mg/mL (50.78 mM; 超声助溶)

    DMSO 中的溶解度 : 3.33 mg/mL (8.46 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5392 mL 12.6958 mL 25.3917 mL
    5 mM 0.5078 mL 2.5392 mL 5.0783 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.24%

    参考文献

    AKT Kinase Inhibitor hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.5392 mL 12.6958 mL 25.3917 mL 63.4792 mL
    5 mM 0.5078 mL 2.5392 mL 5.0783 mL 12.6958 mL
    H2O 10 mM 0.2539 mL 1.2696 mL 2.5392 mL 6.3479 mL
    15 mM 0.1693 mL 0.8464 mL 1.6928 mL 4.2319 mL
    20 mM 0.1270 mL 0.6348 mL 1.2696 mL 3.1740 mL
    25 mM 0.1016 mL 0.5078 mL 1.0157 mL 2.5392 mL
    30 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1160 mL
    40 mM 0.0635 mL 0.3174 mL 0.6348 mL 1.5870 mL
    50 mM 0.0508 mL 0.2539 mL 0.5078 mL 1.2696 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    产品名称:
    AKT Kinase Inhibitor hydrochloride
    目录号:
    HY-10249D
    需求量: