2. PI3K/Akt/mTOR Apoptosis Cell Cycle/DNA Damage Epigenetics
  3. PI3K Apoptosis Caspase PARP
  4. Anticancer agent 137

Anticancer agent 137 (8q) 是一种有效的 PI3k 抑制剂。Anticancer agent 137 具有广谱抗癌活性。Anticancer agent 137 诱导 G2/M 细胞周期停滞和细胞凋亡 (apoptosis)。Anticancer agent 137 增加裂解的PARP、caspase 3 和caspase 7。Anticancer agent 137 可用于癌症研究。

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Anticancer agent 137

Anticancer agent 137 Chemical Structure

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Anticancer agent 137 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A498 GI50
1.38 μM
Compound: 8q
Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human A498 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
ACHN GI50
4.27 μM
Compound: 8q
Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human ACHN cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
COLO 205 GI50
2.4 μM
Compound: 8q
Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human COLO 205 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
DU-145 GI50
2.95 μM
Compound: 8q
Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human DU-145 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
IGROV-1 GI50
2.82 μM
Compound: 8q
Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human IGROV-1 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
KM12 GI50
3.47 μM
Compound: 8q
Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human KM12 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
MDA-MB-435 GI50
0.52 μM
Compound: 8q
Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human MDA-MB-435 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
NCI/ADR-RES GI50
2.82 μM
Compound: 8q
Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human NCI-ADR-RES cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
OVCAR-3 GI50
2.82 μM
Compound: 8q
Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human OVCAR-3 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
OVCAR-4 GI50
2.82 μM
Compound: 8q
Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human OVCAR-4 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
OVCAR-5 GI50
2.82 μM
Compound: 8q
Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human OVCAR-5 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
OVCAR-8 GI50
2.82 μM
Compound: 8q
Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human OVCAR-8 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
PC-3 GI50
1.58 μM
Compound: 8q
Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human PC-3 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
SF-268 GI50
5.13 μM
Compound: 8q
Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human SF-268 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
SF-295 GI50
2.51 μM
Compound: 8q
Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human SF-295 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
SK-MEL-28 GI50
4.07 μM
Compound: 8q
Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human SK-MEL-28 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
SK-OV-3 GI50
2.82 μM
Compound: 8q
Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method
Growth inhibition of human SK-OV-3 cells measured after 24 to 72 hrs by SRB method
[PMID: 37163949]
分子量

449.50

Formula

C26H27NO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 137 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 137Anticancer agent137Anticancer agent-137PI3KApoptosisCaspasePARPPhosphoinositide 3-kinasepoly ADP ribose polymeraseanticancerG2/Mhippo signalingcaspaseInhibitorinhibitorinhibit

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