1. Anti-infection Apoptosis
  2. Parasite Ferroptosis SARS-CoV
  3. Artefenomel

Artefenomel  (Synonyms: OZ439)

目录号: HY-16762 纯度: 98.16%
COA 产品使用指南

Artefenomel (OZ439) 是一种具有口服活性的、合成的含有青蒿素药效团的抗疟疾化合物,具有类似于青蒿素的作用机制。 Artefenomel 具有 SARS-CoV-2 的抗病毒活性。

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Artefenomel Chemical Structure

Artefenomel Chemical Structure

CAS No. : 1029939-86-3

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥2045
In-stock
5 mg ¥4500
In-stock
10 mg ¥7500
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2].

体外研究
(In Vitro)

Artefenomel (OZ439) (10 μg/mL, 2 h) can alkylate Plasmodium falciparum proteins[1].
Artefenomel (0.3-300 μM) reduces ACE2 expression in Vero cells in a dose-dependent manner and does not induce any cytotoxicity at concentrations up to 300 μM[2].
Artefenomel (33-100 μM) can completely prevent the virus-induced CPE and inhibit SARS-CoV-2 in a dose-dependent manner with an IC50 of 2.9 µM[2].
Artefenomel (0-10 µg/mL) affects red blood cells and induces anaemia, thereby inducing histological changes (cell death) and macroscopic abnormalities in the embryo from pregnant Crl:CD(SD)BR rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: embryos from pregnant Crl:CD(SD)BR rats
Concentration: 0.1, 1, 2, 5, 7.5, and 10 µg/mL
Incubation Time:
Result: Showed a slightly shortened tail or slightly delayed telencephalic vesicles at 5 μg/mL, a decrease in the number of circulating red blood cells at 7.5 μg/mL and an arrhythmogenic heartbeat at 10 μg/mL.
Clinical Trial
分子量

469.61

Formula

C28H39NO5

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 4.2 mg/mL (8.94 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1294 mL 10.6471 mL 21.2943 mL
5 mM 0.4259 mL 2.1294 mL 4.2589 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.14%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1294 mL 10.6471 mL 21.2943 mL 53.2357 mL
5 mM 0.4259 mL 2.1294 mL 4.2589 mL 10.6471 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Artefenomel
目录号:
HY-16762
需求量: