2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Anti-infection
  3. STAT Apoptosis Antibiotic
  4. Ascochlorin

Ascochlorin  (Synonyms: Ilicicolin D)

目录号: HY-101021
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摩尔计算器

Ascochlorin (Ilicicolin D)，异戊二烯类抗生素。Ascochlorin 主要通过抑制 STAT3 信号级联介导其抗肿瘤作用。Ascochlorin 诱导细胞凋亡 (apoptosis)。具有抗炎活性。

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Ascochlorin Chemical Structure

Ascochlorin Chemical Structure

CAS No. : 26166-39-2

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规格 价格 是否有货 数量
2.5 mg
询价
500 μg ￥6091
3 - 4 周
1 mg
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Ascochlorin 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity[1][2][3].

IC50 & Target[3]

STAT3

 

Apoptosis

 

体外研究
(In Vitro)

Ascochlorin (Ilicicolin D) (10-50 μM; 24-72 hours) inhibits the viability of HepG2, HCCLM3 and Huh7 cells in a time and dose dependent manner[3].
Ascochlorin (50 μM; 48 hours) induces apoptosis in HCC cells[3].
Ascochlorin (1-50 μM) significantly suppresses the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreases the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Ascochlorin inhibits the mRNA expression and the protein secretion of interleukin (IL)-1β and IL-6 but not tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophage cells. Ascochlorin suppresses nuclear translocation and DNA binding affinity of nuclear factor-κB (NF-κB). Ascochlorin down-regulates phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and p-p38[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ascochlorin 相关抗体:

Cell Viability Assay[3]

Cell Line: HepG2, HCCLM3, Huh7 cells
Concentration: 10, 25, 50 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibit the viability of three different HCC cell lines tested (HepG2, HCCLM3 and Huh7) in a time and dose dependent manner.

Western Blot Analysis[3]

Cell Line: HepG2 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited expression of the cell cycle regulator protein cyclin D1, the anti-apoptotic proteins Bcl-2, Mcl-1, survivin and XIAP, and the invasive gene product MMP-9.
体内研究
(In Vivo)

Ascochlorin (Ilicicolin D) (2.5-5 mg/kg; i.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31) inhibits tumor growth in an orthotopic HCC mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight week-old athymic balb/c nude female mice (HCCLM3-Luc2 tumors)[3]
Dosage: 2.5 mg/kg, 5 mg/kg
Administration: I.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31
Result: Induced significant inhibition of tumor growth.
分子量

404.93

Formula

C23H29ClO4
CAS 号
结构分类
初始来源

Ascochyta viciae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ascochlorin 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Ascochlorin26166-39-2Ilicicolin DSTATApoptosisAntibioticCOX-2HepG2HCCcyclinviabilityathymicbalb/cnudemiceanti-inflammatorytumorInhibitorinhibitorinhibit

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