2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. 5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor
  4. Asenapine citrate

Asenapine citrate  (Synonyms: Org 5222 citrate)

目录号: HY-10121B
产品使用指南

摩尔计算器

Asenapine citrate 属于非典型抗精神药物，是 5-羟色胺受体 (5-HT receptors，pKi: 8.4-10.5)、肾上腺素受体 (adrenoceptors，pKi: 8.9-9.5)、多巴胺受体 (dopamine receptors，pKi: 8.9-9.4) 和组胺受体 (histamine receptors，pKi: 8.2-9.0) 多种受体的拮抗剂。Asenapine citrate 可用于精神分裂症和双相情感障碍的研究。

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Asenapine citrate Chemical Structure

Asenapine citrate Chemical Structure

CAS No. : 1411867-74-7

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规格 是否有货
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Asenapine citrate 的其他形式现货产品:

Customer Review

Other Forms of Asenapine citrate:

Asenapine citrate 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].

IC50 & Target

5-HT1B Receptor

8.4 (pKi)

5-HT1A Receptor

8.6 (pKi)

5-HT5 Receptor

8.8 (pKi)

5-HT6 Receptor

9.6 (pKi)

5-HT2B Receptor

9.8 (pKi)

5-HT7 Receptor

9.9 (pKi)

5-HT2A Receptor

10.2 (pKi)

5-HT2C Receptor

10.5 (pKi)

α1-adrenergic receptor

8.9 (pKi)

Alpha-2A adrenergic receptor

8.9 (pKi)

Alpha-2C adrenergic receptor

8.9 (pKi)

Alpha-2B adrenergic receptor

9.5 (pKi)

D1 Receptor

8.9 (pKi)

D2 Receptor

8.9 (pKi)

D4 Receptor

9.0 (pKi)

D3 Receptor

9.4 (pKi)

H2 Receptor

8.2 (pKi)

H1 Receptor

9.0 (pKi)

体内研究
(In Vivo)

Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

477.89

Formula

C23H24ClNO8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Asenapine citrate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asenapine1411867-74-7Org 5222Org5222Org-52225-HT ReceptorDopamine ReceptorAdrenergic ReceptorHistamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorpsychopharmacologicpsychopharmacologicaldopamineserotoninnoradrenalinenorepinephrinehistamineschizophreniabipolar disorderantidepressantInhibitorinhibitorinhibit

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目录号：
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