2. 诱导疾病模型产品 Immunology/Inflammation Anti-infection NF-κB Autophagy Apoptosis MAPK/ERK Pathway
  3. 免疫与炎症疾病模型 消化系统疾病模型 COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK
  4. 胃肠炎症及溃疡模型 胃肠道疾病模型
  5. 胃溃疡模型
  6. Aspirin lithium

Aspirin lithium  (Synonyms: Acetylsalicylic acid lithium; ASA lithium)

目录号: HY-14654A
产品使用指南 技术支持

Aspirin (Acetylsalicylic Acid) lithium 是一种口服有效的不可逆的环氧合酶 COX-1 和 COX-2 抑制剂，IC50 分别为 5 和 210 μg/mL. Aspirin lithium 诱导细胞凋亡 (apoptosis)。Aspirin lithium 可抑制 NF-κB 的活化。Aspirin lithium 还抑制血小板前列腺素合成酶 (prostaglandin synthetase)，可预防冠状动脉和脑血管血栓形成。

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Aspirin lithium

Aspirin lithium Chemical Structure

CAS No. : 552-98-7

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Aspirin lithium 的其他形式现货产品:

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Other Forms of Aspirin lithium:

Aspirin lithium 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 29 篇科研文献

WB

    Aspirin lithium purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

    查看 COX 亚型特异性产品:

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    COX COX-1 COX-2 COX-3

    查看 NF-κB 亚型特异性产品:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    查看 Caspase 亚型特异性产品:

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    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

    查看 p38 MAPK 亚型特异性产品:

    查看所有亚型
    p38 MAPK p38α p38β MAPK13 p38δ p38γ

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].

    IC50 & Target

    COX-1

     

    COX-2

     

    体外研究
    (In Vitro)

    Aspirin lithium 抑制人关节软骨细胞中的 COX-1 和 COX-2，IC50 值分别为 3.57 μM 和 29.3 μM[2]。
    Aspirin acetylates COX-1 的丝氨酸 530，从而阻断血小板中血栓素 A 的合成，减少血小板聚集[3]。
    Aspirin lithium 通过干扰 CCAAT/增强子结合抑制 COX-2 蛋白表达蛋白质 beta (C/EBPbeta) 与其在 COX-2 启动子/增强子上的同源位点[3]。
    Aspirin lithium 抑制 NF-κB 依赖性转录自 lgκ 增强子和人类免疫缺陷病毒 (HIV) 转染 T 细胞中的长末端重复序列 (LTR)[4]。
    Aspirin lithium 通过激活半胱天冬酶、激活 p38 MAP 激酶、释放线粒体细胞色素 c、和神经酰胺途径的激活[6]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Aspirin lithium 相关抗体:
    体内研究
    (In Vivo)

    注意：
    请勿仅参考一篇文章来确定实验条件。建议在正式实验前，通过预实验确定最佳实验条件 (动物品系、年龄、剂量、频率及周期、检测时间及指标等)。

    Aspirin lithium (5-150 mg/kg，口服，一次) 对成年酵母菌发热雄性大鼠表现出显著的解热活性[2]。
    Aspirin 可用于诱导胃肠溃疡模型[8]。

    诱导胃肠溃疡模型[8]
    致病原理
    Aspirin 可抑制动物内源性前列腺素（PG）的合成。Aspirin 还能溶解粘膜上皮细胞的磷脂，导致粘膜通透性增加。
    具体造模方法：
    小鼠：白化病小鼠 • 雄性 • 6 周龄
    给药方式：500 mg/kg • oral • 单剂量
    造模成功指标
    组织学改变: 造成表皮上皮细胞的侵蚀。
    导致粘膜厚度减少。
    无COX-1反应诱发溃疡。
    相关产品：/
    拮抗产品：/

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 mL/kg of a 20% aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)[7]
    Dosage: 5, 25, 50, 100 and 150 mg/kg
    Administration: PO, once
    Result: Produced a statistically significant decrease of 0.23°C at 15 min post-drug at the dose of 150 mg/kg. Antipyretic effect gradually increased in magnitude until a peak effect of 1.96 °C was reached at 120 min post-drug. The ED50 of aspirin was found to be 10.3 mg/kg with confidence limits of 1.8-23.0 mg/kg. The antipyretic response to aspirin is dependent on the dose of the compound administered.
    Animal Model: Albino male mice [8]
    Dosage: 500 mg/kg, single dose
    Administration: oral
    Result: Caused erosion of the surface epithelial cells.
    Resulted in a decrease in the mucosal thickness.
    Induced ulcer without COX-1 reaction.
    Clinical Trial
    分子量

    186.09

    Formula

    C9H7LiO4
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Aspirin lithium 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aspirin552-98-7Acetylsalicylic acidASACOXVirus ProteaseNF-κBAutophagyApoptosisMitophagyCaspasep38 MAPKCyclooxygenaseNuclear factor-κBNuclear factor-kappaBMitochondrial AutophagyAntipyretic effectfeverinflammationcerebrovascular thrombosiscoronary arteryplateletprostaglandin synthetasecancerInhibitorinhibitorinhibit

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