2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. AZD1092

AZD1092 是一种葡萄糖激酶 (GK) 激活剂，EC50 值为 0.03 μM，具有口服活性。 AZD1092 可用于 2 型糖尿病 (T2D) 的研究。

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AZD1092 Chemical Structure

AZD1092 Chemical Structure

CAS No. : 871656-65-4

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AZD1092 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D)[1].

IC50 & Target

EC50: 0.03 μM (glucokinase)[1]
体外研究
(In Vitro)

AZD1092 对葡萄糖激酶具有活性，EC50 值为 0.03 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZD1092 相关抗体:
体内研究
(In Vivo)

AZD1092 (oral; 1, 3, 10 mg/kg) 呈剂量依赖性降低 Zucker 大鼠血糖波动，具有降糖作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Zucker rats[1]
Dosage: 1, 3, 10 mg/kg
Administration: Oral
Result: Exhibited dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats and glucose lowering efficacy in free feeding glucose profiles in male Zucker rats.
分子量

450.49

Formula

C24H26N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZD1092 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD1092871656-65-4AZD 1092AZD-1092GlucokinaseHexokinase IVHexokinase DType 2 Diabetes (T2D)glucokinaseglycaemic controlInhibitorinhibitorinhibit

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