1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. Balixafortide TFA

Balixafortide TFA (Synonyms: POL6326 TFA)

目录号: HY-P1682A 纯度: 98.19%
产品使用指南

Balixafortide TFA (POL6326 TFA) 是一种有效的,选择性的,耐受性好的肽类 CXCR4 拮抗剂,其 IC50 小于 10 nM。Balixafortide TFA 对 CXCR4 的选择性比包括 CXCR7 在内的许多受体高出 1000 倍。Balixafortide TFA 以 IC50 < 10 nM 阻断 β-arrestin 募集和钙通量。Balixafortide TFA 还是一种有效的造血干细胞和祖细胞 (HSPC) 动员剂,并具有抗癌作用。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Balixafortide TFA Chemical Structure

Balixafortide TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
5 mg ¥1700 In-stock
25 mg ¥6200 In-stock
50 mg ¥10500 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of Balixafortide TFA:

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1][2].

IC50 & Target[1]

CXCR4

<10 nM (IC50)

In Vitro

Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC50< 200 nM) and Jurkat (IC50 < 400 nM). Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC50 < 20 nM), Namalwa and Jurkat cells (IC50 < 10 nM)[1].

In Vivo

Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability[1].

Clinical Trial
Molecular Weight

1896.05

Formula

C₈₂H₁₁₃N₂₂F₃O₂₃S₂

Sequence

Cyclo(Ala-Cys-Ser-Ala-Pro-{Dab}-Arg-Tyr-Cys-Tyr-Gln-Lys-Pro-Pro-Tyr-His)(Disulfide bridge: Cys2-Cys9)

Sequence Shortening

Cyclo(ACSAP-{Dab}-RYCYQKPPYH)(Disulfide bridge: Cys2-Cys9)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BalixafortidePOL6326POL 6326POL-6326CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR4well-toleratedHSPCanti-cancerangiogenesismetastaticβ-arrestinchemotaxisrecruitmentInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Balixafortide TFA
目录号:
HY-P1682A
需求量: