2. Immunology/Inflammation Apoptosis
  3. COX Bcl-2 Family Caspase Apoptosis
  4. COX-2-IN-59

COX-2-IN-59 是一种高效且选择性的 COX-2 抑制剂，IC50 值为 0.052 μM。COX-2-IN-59 对 COX-2 的选择性是对 COX-1 的 200 倍以上 (对 COX-1 的 IC50 值为 11.16 μM)。COX-2-IN-59 能够降低 COX-2 水平，诱导细胞周期阻滞，并通过上调 Bax 表达、下调 Bcl-2 水平以及激活 caspase-3 来触发细胞凋亡 (apoptosis)。COX-2-IN-59 可用于结肠癌的相关研究。

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COX-2-IN-59

COX-2-IN-59 Chemical Structure

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Customer Review

COX-2-IN-59 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 μM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer[1].

IC50 & Target[1]

COX-2

0.052 μM (IC50)

COX-1

11.16 μM (IC50)

体外研究
(In Vitro)

COX-2-IN-59 (compound 5d) (12.5-100 μM; 24 h) 抑制 A-549、HOS、MCF-7、HT-29、PC3 和 Caco-2 细胞的生长，IC50 分别为 4、67.3、30.5、8.5、29.1 和 2.6 μM[1]。
COX-2-IN-59 (2.6 μM; 24 h) 诱导 G1/S 细胞周期阻滞，并通过增加 Bax 表达、降低 Bcl-2 水平和激活 caspase-3 来触发 Caco-2 细胞凋亡[1]。
COX-2-IN-59 (2.6 μM; 24 h) 能显著降低 Caco-2 细胞中的 COX-2 水平，使其降至 3.858 ng/mL (相对于对照组，降低了 0.494 倍)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-59 相关抗体:

Cell Viability Assay[1]

Cell Line: A-549, HOS, MCF-7, HT-29, PC3, and Caco-2 cells
Concentration: 12.5-100 μM
Incubation Time: 24 h
Result: Inhibited A-549, HOS, MCF-7, HT-29, PC3, and Caco-2 cell growth with IC50s of 4, 67.3, 30.5, 8.5, 29.1, and 2.6 μM, respectively.

Apoptosis Analysis[1]

Cell Line: Caco-2
Concentration: 2.6 μM
Incubation Time: 24 h
Result: Demonstrated potent proapoptotic activity in Caco-2 cells, inducing a nearly eightfold increase in total apoptosis (24.38% vs. 3.16% in controls). Induced a dramatic 63-fold increase (15.86% vs. 0.25%) in late apoptosis, and an 11-fold increase (4.85% vs. 0.42%) in early apoptosis.

Cell Cycle Analysis[1]

Cell Line: Caco-2
Concentration: 2.6 μM
Incubation Time: 24 h
Result: Showed a dramatic decrease in G2/M phase cells in the treated group (3.82%) compared to the control group (22.05%). Significantly increased cells in the G0/G1 phase (64.06% vs. 48.29% in control). Induced G1/S phase cell cycle arrest.

Western Blot Analysis[1]

Cell Line: Caco-2
Concentration: 2.6 μM
Incubation Time: 24 h
Result: Induced the expression of Bax while suppressing the expression of Bcl‐2, ultimately leading to an increased expression of caspase‐3.

ELISA Assay[1]

Cell Line: Caco-2
Concentration: 2.6 μM
Incubation Time: 24 h
Result: Significantly reduced COX-2 levels to 3.858 ng/mL (0.494‐fold relative to control).
分子量

405.42

Formula

C18H19N3O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2-IN-59 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-59COXBcl-2 FamilyCaspaseApoptosisCyclooxygenaseCOX-2,colon cancer,Caco-2Inhibitorinhibitorinhibit

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