DPLG3 

DPLG3 is a specific chymotryptic-like β5i subunits inhibitor, with an IC₅₀ of 4.5 nM. DPLG3 inhibits mouse i-20S with IC₅₀ of 9.4 nM. DPLG3 downregulates the protein levels of NF-κB p50 and p65. DPLG3 can be used for immune disease research^[1][2][3].

DPLG3 (1-5 µM, 2 h) 下调从 6-8 周龄 C57BL/6 小鼠胫骨和股骨分离的 BMDMs 细胞中 NF-κB p50 和 p65 的蛋白质水平^[1]。
DPLG3 (0.5-5 µM) 以浓度依赖性方式抑制 T 细胞增殖^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DPLG3 (2.5-5 mg/kg，腹腔注射，每日一次，从第 0 天开始直至第 12 天) 可减缓 DSS 诱发的实验性结肠炎小鼠的病情进展^[1]。
DPLG3 (25 mg/kg，腹腔注射，每日一次，14 天) 可延长小鼠心脏同种异体移植存活时间 (将 BALB/c 小鼠心脏移植到完全同种异体的 C57BL/6 小鼠受体中)^[2]。
DPLG3 (25 mg/kg) 减少移植 CD3⁺ CD25^- T 细胞的 RAG^-/- C57BL/6 小鼠体内 CD4⁺ 和 CD8⁺ 效应 T 细胞^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

640.74

C₃₇H₄₁FN₄O₅

1801379-22-5

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Moallemian R, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation. Biochem Pharmacol. 2020 Jul;177:113964.  [Content Brief]

  [2]. Sula Karreci E, et al. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8425-E8432.  [Content Brief]

  [3]. Basler M, et al. On the role of the immunoproteasome in transplant rejection. Immunogenetics. 2019 Mar;71(3):263-271.  [Content Brief]