Enapotamab  (Synonyms: Anti-AXL/UFO Reference Antibody (enapotamab))

Enapotamab (Anti-AXL/UFO Reference Antibody) is an AXL/UFO-related antibody that can be used for synthesis of ADC molecule Enapotamab vedotin (HY-P99921)^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

Enapotamab 可作为 ADC 抗体用于合成 Enapotamab vedotin (HY-P99921)。
Enapotamab vedotin 在 AXL 高表达的 NSCLC 细胞中表现出细胞毒性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enapotamab vedotin 对多种 AXL 高表达的 NSCLC 肿瘤均表现出抗肿瘤作用，并且在 LU1868 异种移植小鼠模型中也表现出对 EGFR 抑制剂的耐药性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

558  [NCBI]

P30530

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

143.895 kDa

1912423-61-0

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG1 kappa

• 
  Loaded Enapotamab on AHC2 biosensor, can bind AXL Protein, Human (449a.a, HEK293, His, HY-P74407) with an affinity constant of 6.653E-09 M as determined in BLI assay.
• 
  Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Enapotamab. The EC₅₀ for this effect is 0.3126 ng/mL.

• [1]. Matthew T. Burger, et al. Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof. WO2022115477A1.

  [2]. Koopman LA, et al. Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight. 2019 Nov 1;4(21):e128199.  [Content Brief]