2. Anti-infection
  3. Bacterial Antibiotic
  4. Ertapenem disodium

Ertapenem disodium  (Synonyms: MK-0826 disodium)

目录号: HY-A0294A
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摩尔计算器

Ertapenem (MK-0826) disodium 是一种广谱的长效 β-内酰胺抗生素。Ertapenem disodium 对多种厌氧菌具有广谱抗菌活性，其 MIC 值为 0.12 μg/mL。Ertapenem disodium 可用于皮肤、肺、胃、骨盆和泌尿道的细菌感染相关的研究。

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Ertapenem disodium Chemical Structure

Ertapenem disodium Chemical Structure

CAS No. : 153832-38-3

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规格 价格 是否有货
1 mg ￥1280
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5 mg ￥3590
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10 mg ￥5750
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Ertapenem disodium 的其他形式现货产品:

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Other Forms of Ertapenem disodium:

Ertapenem disodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ertapenem (MK-0826) disodium is a broad spectrum and long acting β-lactam antibiotic. Ertapenem disodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem disodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Ertapenem disodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ertapenem disodium 相关抗体:

Cell Viability Assay[1]

Cell Line: B. fragilis (ATCC 25285), B. thetaiotaomicron (ATCC 29741), and Eubacterium lentum (ATCC 43055)
Concentration: 0-100 μg/mL approximately
Incubation Time: 48 h
Result: Inhibited 99.1% of all isolate with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and 98.8% of the isolates were susceptible among the B. fragilis group.
体内研究
(In Vivo)

Ertapenem disodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log10 CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg[2].
Ertapenem disodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of <0.25 mg/kg/dose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: S. aureus thigh tissue infection model (DBA/2 mice)[2]
Dosage: 0.5,1, 2, 5, 10 mg/kg (given at 2, 6, 10, 24, 48, 72, 96, 120 h)
Administration: Subcutaneous injection (0.5 mL after infection)
Result: Displayed > 3 log10 CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg.
Maintained the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.
Animal Model: Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)[2]
Dosage: 0-3 mg/kg approximately
Administration: Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result: Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED50s of <0.25 mg/kg/dose.
Animal Model: CD-1 mice, rats[2]
Dosage: 10 mg/kg approximately
Administration: Intraperitoneal injection (pharmacokinetic assay)
Result: Exhibited an AUC0-∞ ranging from 1.8-21.82 μg•hr/mL in tissue in mice following a 10-mg/kg i.p. dose.
Exhibited slow clearance rate with a t1/2β of 3.2 h, Clp of 0.47 mL/min/kg, AUC0-8 of 284.15μg•hr/mL.
Clinical Trial
分子量

519.48

Formula

C22H23N3Na2O7S
CAS 号
性状

固体

颜色

White to off-white

中文名称

厄他培南
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Ertapenem disodium 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ertapenem disodium153832-38-3MK-0826 disodium厄他培南BacterialAntibioticAnaerobes infectionantibioticanaerobic bacteriaInhibitorinhibitorinhibit

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