2. Gene
  3. BRAF - B-Raf proto-oncogene, serine/threonine kinase Gene

BRAF - B-Raf proto-oncogene, serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：B-Raf 原癌基因， 丝氨酸/苏氨酸激酶

种属: Sus scrofa

基因 ID: 100514612 | 基因类型: protein coding

关于 BRAF

Primary_assembly 18: 8,957,991-9,132,553 forward strand.Sscrofa11.1:CM000829.5

This gene has 4 transcripts (splice variants), 220 orthologues and 23 paralogues. Ubiquitous expression in kidney (RPKM 3.3), lung (RPKM 3.1) and 8 other tissues.

BRAF 基因产物(7)

mRNA Protein Name
XM_005654267.3 XP_005654324.1 serine/threonine-protein kinase B-raf isoform X6
XM_021078583.1 XP_020934242.1 serine/threonine-protein kinase B-raf isoform X1
XM_021078584.1 XP_020934243.1 serine/threonine-protein kinase B-raf isoform X2
XM_021078585.1 XP_020934244.1 serine/threonine-protein kinase B-raf isoform X3
XM_021078587.1 XP_020934246.1 serine/threonine-protein kinase B-raf isoform X5
XM_021078586.1 XP_020934245.1 serine/threonine-protein kinase B-raf isoform X4
XM_021078588.1 XP_020934247.1 serine/threonine-protein kinase B-raf isoform X6

BRAF 蛋白结构

RBD_BRAF

RBD_BRAF: cd17134 (150 - 228)

C1_B-Raf

C1_B-Raf: cd20871 (226 - 285)

STKc_Raf

STKc_Raf: cd14062 (471 - 723)

  • 0
  • 200
  • 400
  • 600
  • 776 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase B-raf

v-raf murine sarcoma viral oncogene homolog B

v-raf murine sarcoma viral oncogene homolog B1

相关产品

Approval
生物活性分子 (9)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10201 Sorafenib Inhibitor 99.92% 是
HY-14660 Dabrafenib Inhibitor 99.91% 是
HY-12057 Vemurafenib Inhibitor 99.83% 是
HY-10331 Regorafenib Inhibitor 99.93% 是
HY-10201A Sorafenib Tosylate Inhibitor 99.91% 是
HY-14660A Dabrafenib Mesylate Inhibitor 99.95% 是
HY-10331A Regorafenib monohydrate Inhibitor 99.96% 是
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% 是
HY-10331B Regorafenib mesylate Inhibitor / 否
Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-10320 Doramapimod Inhibitor 99.98% Phase 2
HY-109080 Belvarafenib Inhibitor 99.71% Phase 2
HY-112089 Naporafenib Inhibitor 99.72% Phase 2
HY-18957 Lifirafenib Inhibitor 98.73% Phase 2
HY-153341 CFT1946 Degrader 99.84% Phase 2
HY-111940 LUT014 Inhibitor 97.23% Phase 2
HY-18652 Avutometinib Inhibitor 98.99% Phase 1
HY-12558 LY3009120 Inhibitor 98.97% Phase 1
HY-15200 Agerafenib Inhibitor 99.63% Phase 1
HY-19343 XL-281 Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (44)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10966 SB-590885 Inhibitor 99.77% 否
HY-51424 PLX-4720 Inhibitor 99.91% 否
HY-50864 GDC-0879 Inhibitor 99.69% 否
HY-11004 AZ 628 Inhibitor 99.85% 否
HY-15767 TAK-632 Inhibitor 98.84% 否
HY-18997 PLX7904 Inhibitor 98.94% 否
HY-12846 CCT196969 Inhibitor 99.63% 否
HY-18972 Plixorafenib Inhibitor 99.94% 否
HY-107779 BI-882370 Inhibitor 99.16% 否
HY-14177 Raf inhibitor 1 Inhibitor 98.11% 否
HY-100510 RAF709 Inhibitor 99.45% 否
HY-12787 L-779450 Inhibitor 98.75% 否
HY-77113 B-Raf IN 11 Inhibitor 99.46% 否
HY-12291 HG6-64-1 Inhibitor ≥98.0% 否
HY-10247 BRAF inhibitor Inhibitor 98.97% 否
HY-147405 Tinlorafenib Inhibitor 98.20% 否
HY-142160 GNE-9815 Inhibitor 98.28% 否
HY-111758 PROTAC B-Raf degrader 1 Inhibitor 99.78% 否
HY-137487 PROTAC BRAF-V600E degrader-1 Inhibitor 98.02% 否
HY-117273 AZ304 Inhibitor 99.96% 否
HY-148059 Uplarafenib Inhibitor 99.15% 否
HY-145120 B-Raf IN 2 Inhibitor 99.27% 否
HY-18227 B-Raf IN 1 Inhibitor 98.66% 否
HY-18507 AD57 Inhibitor 98.08% 否
HY-15198 KG5 Inhibitor 99.79% 否
HY-126298 RAF mutant-IN-1 Inhibitor / 否
HY-18318 Takeda-6D Inhibitor / 否
HY-137488 PROTAC BRAF-V600E degrader-2 Inhibitor / 否
HY-144271 RAF-IN-1 Inhibitor / 否
HY-147852 B-Raf IN 7 Inhibitor / 否
HY-12847 CCT241161 Inhibitor / 否
HY-115933 EGFR/BRAF-IN-1 Inhibitor / 否
HY-149415 Multi-kinase-IN-5 Inhibitor / 否
HY-16063 ARQ-736 Inhibitor / 否
HY-146491 VEGFR-2/BRAF-IN-1 Inhibitor / 否
HY-146492 VEGFR-2/BRAF-IN-2 Inhibitor / 否
HY-147854 B-Raf IN 9 Inhibitor / 否
HY-147853 B-Raf IN 8 Inhibitor / 否
HY-13810 PF-04880594 Inhibitor / 否
HY-150250 B-Raf IN 13 Inhibitor / 否
HY-144269 SHR902275 Inhibitor / 否
HY-15199 Agerafenib hydrochloride Inhibitor / 否
HY-14177A Raf inhibitor 1 dihydrochloride Inhibitor / 否
HY-120676 B-Raf IN 18 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens BRAF NCBI NCBI:673
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