Jak3 - Janus kinase 3 Gene

中文名称：两面神激酶 3

种属: Mus musculus

同用名: fae; wil

关于 Jak3

功能概要

该基因编码的蛋白可启动蛋白酪氨酸激酶活性。参与多个过程，包括 FasL 生产的负调节；细胞因子产生的负调节；和细胞凋亡过程的调节。作用于多个过程的上游或内部，包括细胞表面受体信号通路；肽基酪氨酸磷酸化；和 RNA 聚合酶 II 对转录的正调控。预计位于细胞质中。以多种结构表达，包括消化系统；脑;泌尿生殖系统；淋巴系统腺体；以及肝脏和胆道系统。用于研究严重联合免疫缺陷、常染色体隐性遗传、T 细胞阴性、B 细胞阳性、Nk 细胞阳性。与 T 细胞急性淋巴细胞白血病有关的该基因的人类直系同源物；急性巨核细胞白血病；成人 T 细胞白血病；和幼年型粒单核细胞白血病。与人 JAK3（Janus 激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of FasL production; negative regulation of cytokine production; and regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute megakaryocytic leukemia; adult T-cell leukemia; and juvenile myelomonocytic leukemia. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Apr 2022]