2. Gene
  3. Lox - lysyl oxidase Gene

Lox - lysyl oxidase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: rrg; TSC-160

基因 ID: 16948 | 基因类型: protein coding

关于 Lox

功能概要

This gene encodes a precursor protein that belongs to the Lysyl Oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of Collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Lox 基因产物(3)

mRNA Protein Name
NM_001286181.1 NP_001273110.1 protein-lysine 6-oxidase preproprotein
NM_001286182.1 NP_001273111.1 protein-lysine 6-oxidase preproprotein
NM_010728.4 NP_034858.2 protein-lysine 6-oxidase preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16251195 MGI
enables protein-lysine 6-oxidase activity IDA
IDA: 通过直接分析推断
14140 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA biosynthetic process IMP
IMP: 通过突变表型推断
19458888 MGI
acts upstream of or within aorta development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within ascending aorta development IMP
IMP: 通过突变表型推断
28550176 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
12417550 MGI
involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
27432961 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
19458888 MGI
acts upstream of or within cell chemotaxis IMP
IMP: 通过突变表型推断
18586678 MGI
acts upstream of or within cellular response to chemokine IMP
IMP: 通过突变表型推断
18586678 MGI
acts upstream of or within collagen fibril organization IMP
IMP: 通过突变表型推断
26700732 MGI
acts upstream of or within connective tissue development IGI
IGI: 通过遗传相互作用推断
25715398 MGI
acts upstream of or within descending aorta development IMP
IMP: 通过突变表型推断
28550176 MGI
acts upstream of or within elastic fiber assembly IMP
IMP: 通过突变表型推断
12417550 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
16192629 MGI
acts upstream of or within muscle cell cellular homeostasis IGI
IGI: 通过遗传相互作用推断
25715398 MGI
acts upstream of or within muscle cell development IMP
IMP: 通过突变表型推断
25715398 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
28538980 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
28538980 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
19458888 MGI
acts upstream of or within platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: 通过突变表型推断
18586678 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: 通过突变表型推断
28538980 MGI
acts upstream of or within regulation of bone development IMP
IMP: 通过突变表型推断
21665949 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
28285904 MGI
acts upstream of or within regulation of megakaryocyte differentiation IMP
IMP: 通过突变表型推断
21665949 MGI
acts upstream of or within regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: 通过突变表型推断
21665949 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18835815 MGI
acts upstream of or within regulation of receptor binding IMP
IMP: 通过突变表型推断
18586678 MGI
acts upstream of or within regulation of striated muscle tissue development IMP
IMP: 通过突变表型推断
25715398 MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
25715398 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of collagen trimer IDA
IDA: 通过直接分析推断
7901452 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
9382709 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
27432961 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein-lysine 6-oxidase

ras excision protein

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13948 Angiotensin II human 99.98% 否
HY-13948A Angiotensin II human acetate 99.81% 否
HY-A0060 Malotilate Inhibitor 99.47% 否
HY-13948B Angiotensin II human TFA 98.84% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-N0198 Nordihydroguaiaretic acid 99.93% Phase 4
HY-106835 Flobufen Inhibitor / Phase 3
HY-117048 PF-4191834 Inhibitor 99.77% Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99646 Golocdacimab Inhibitor 99.09% Phase 2
Pre-clinical Phase
生物活性分子 (131)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y1750 β-Aminopropionitrile Inhibitor 99.99% 否
HY-12341 ML355 Inhibitor 98.11% 否
HY-N0551 Wedelolactone 99.91% 否
HY-111310 ML351 Inhibitor 99.16% 否
HY-138153 JKE-1674 99.54% 否
HY-23999 BI-0115 99.71% 否
HY-113439 12-HETE Inhibitor 95.70% 否
HY-138625 LOX-IN-3 Inhibitor 99.97% 否
HY-42484 ER-076349 Inhibitor 99.72% 否
HY-N1996 Chebulagic acid Inhibitor 99.66% 否
HY-N0232 Psoralidin 99.90% 否
HY-B1452 Licofelone 99.84% 否
HY-N0493 Pectolinarigenin Inhibitor 99.79% 否
HY-N7108 7-Hydroxyflavone 99.84% 否
HY-N2056 11-​Keto-​beta-​boswellic acid Inhibitor 99.96% 否
HY-N2176 S-(+)-Marmesin Inhibitor 99.73% 否
HY-138989 15-LOX-1 inhibitor 1 Inhibitor 98.81% 否
HY-N1881 4',5-Dihydroxyflavone Inhibitor 99.95% 否
HY-138625A LOX-IN-3 dihydrochloride Inhibitor 99.88% 否
HY-105024 FPL 62064 Inhibitor 99.25% 否
HY-151499A PXS-6302 hydrochloride Inhibitor 99.83% 否
HY-113884B (S)-Coriolic acid Activator ≥99.0% 否
HY-N1942 5-O-Demethylnobiletin Inhibitor 99.91% 否
HY-124674A CCT365623 hydrochloride 98.07% 否
HY-149922 DKI5 Inhibitor 98.12% 否
HY-139196 ThioLox Inhibitor 99.74% 否
HY-N7012 7,3',4'-Tri-O-methylluteolin 99.28% 否
HY-W009248 Phenethyl ferulate Inhibitor 99.66% 否
HY-W010144 Phenidone Inhibitor 99.00% 否
HY-10439 HPGDS inhibitor 1 Inhibitor 99.42% 否
HY-121585 CAY10698 Inhibitor 99.28% 否
HY-127170 3-Hydroxycoumarin Inhibitor 99.30% 否
HY-128171 Diflapolin Inhibitor 99.67% 否
HY-138939 5-LOX-IN-2 Inhibitor 98.75% 否
HY-148134 5-LOX-IN-1 Inhibitor 98.04% 否
HY-170573A LOXL2-IN-1 tosylate Inhibitor 99.90% 否
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% 否
HY-169021 JNK-1-IN-3 Inhibitor 98.44% 否
HY-113439S 12-HETE-d8 Inhibitor ≥98.0% 否
HY-111140 YS121 Inhibitor 99.74% 否
HY-118110 MLS000545091 Inhibitor 99.92% 否
HY-118480 4-MMPB 98.54% 否
HY-125975 1-Naphthyl 3,5-dinitrobenzoate Inhibitor 99.49% 否
HY-151498 PXS-4787 Inhibitor / 否
HY-151499 PXS-6302 Inhibitor / 否
HY-158204 CNB-001 Inhibitor / 否
HY-170538 SNT-5382 Inhibitor 99.93% 否
HY-P2976 Lipoxygenase, general / 否
HY-W488004 KKII5 Inhibitor 98.60% 否
HY-155244 12R-LOX-IN-2 Inhibitor 99.85% 否
HY-U00308 5-LOX-IN-4 Inhibitor 98.07% 否
HY-W009671 3-Chloroiminodibenzyl Inhibitor 99.60% 否
HY-138625B LOX-IN-3 dihydrochloride monohydrate Inhibitor / 否
HY-113115A L-Allysine / 否
HY-114796 tHGA Inhibitor / 否
HY-114873 LY256548 Inhibitor / 否
HY-116124 17(S)-HpDHA / 否
HY-116763 COX-2/5-LOX-IN-4 Inhibitor / 否
HY-116866 Sclerotiorin Inhibitor / 否
HY-116919 MLS000536924 Inhibitor / 否
HY-117514 5-LOX-IN-7 Inhibitor / 否
HY-120502 5-LOX-IN-6 Inhibitor / 否
HY-124674 CCT365623 / 否
HY-124722 OHM1 Inhibitor / 否
HY-139055 NCTT-956 Inhibitor / 否
HY-145473 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE / 否
HY-146294 COX-2/5-LOX-IN-1 Inhibitor / 否
HY-146295 COX-2/5-LOX-IN-2 / 否
HY-147870 COX-2-IN-22 Inhibitor / 否
HY-147951 COX-2/5-LOX-IN-3 Inhibitor / 否
HY-149269 COX-2-IN-30 Inhibitor / 否
HY-149270 COX-2-IN-31 Inhibitor / 否
HY-149476 5-LOX-IN-5 Inhibitor / 否
HY-150548 COX-2/15-LOX-IN-1 Inhibitor / 否
HY-150550 COX-2-IN-26 Inhibitor / 否
HY-150551 COX-2-IN-27 Inhibitor / 否
HY-150553 COX-2-IN-28 Inhibitor / 否
HY-151173 XO/COX/LOX-IN-1 Inhibitor / 否
HY-151426 Anticancer agent 83 Inducer / 否
HY-153279 5-LOX-IN-3 Inhibitor / 否
HY-153930 h15-LOX-2 inhibitor 1 Inhibitor / 否
HY-155123 Antioxidant agent-13 Inhibitor / 否
HY-155159 COX-2/15-LOX-IN-2 Inhibitor / 否
HY-155160 COX-2/15-LOX-IN-3 Inhibitor / 否
HY-155161 COX-2/15-LOX-IN-4 Inhibitor / 否
HY-155243 12R-LOX-IN-1 Inhibitor / 否
HY-155409 ALR-38 Antagonist / 否
HY-155522 WES-1 Inhibitor / 否
HY-156329 sEH/FLAP-IN-1 Inhibitor / 否
HY-159169 5-LOX/sEH-IN-1 Inhibitor / 否
HY-161315 15-LOX-IN-1 Inhibitor / 否
HY-162166 COX-2/15-LOX/mPGES1-IN-1 Inhibitor / 否
HY-162523 hMAO-B-IN-8 Inhibitor / 否
HY-162830 5-LOX/MAOs-IN-1 Inhibitor / 否
HY-163187 COX-2/LOX-IN-1 Inhibitor / 否
HY-163188 COX-2/LOX-IN-2 Inhibitor / 否
HY-163355 COX-2/15-LOX-IN-5 Inhibitor / 否
HY-163736 mPGES-1/5-LOX-IN-1 Inhibitor / 否
HY-168340 COX-2/15-LOX-IN-6 Inhibitor / 否
HY-168632 Topoisomerase I/II inhibitor 6 / 否
HY-170573 LOXL2-IN-1 Inhibitor / 否
HY-170938 AChE-IN-82 Inhibitor / 否
HY-170957 5-LOX/NO-IN-1 Inhibitor / 否
HY-171955 LXG6403 / 否
HY-172790 Cbz-(S,S)-Pro-Pro-allyl Inhibitor / 否
HY-172877 EGFR/BRAFV600E-IN-5 / 否
HY-173056 Ruthenoleuton Inhibitor / 否
HY-173115 15-LOX-IN-2 / 否
HY-173180 5-LOX-IN-8 Inhibitor / 否
HY-B1452S1 Licofelone-d6 / 否
HY-N2266 Benzoylgomisin O Inhibitor / 否
HY-N8480 Atractylochromene Inhibitor / 否
HY-N8764 Decaffeoylacteoside Inhibitor / 否
HY-P10458 5-Lipoxygenase blocking peptide Inhibitor / 否
HY-RS07739 LOX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-Y1750A β-Aminopropionitrile hydrochloride Inhibitor / 否
HY-113807 ZLJ-6 Inhibitor / 否
HY-118268 RG 6866 Inhibitor / 否
HY-118848 A63162 Inhibitor / 否
HY-133215 Zileuton sulfoxide Inhibitor / 否
HY-155407 ALR-6 Antagonist / 否
HY-155408 ALR-27 Antagonist / 否
HY-161907 h15-LOX-2 inhibitor 2 Inhibitor / 否
HY-161908 h15-LOX-2 inhibitor 3 Inhibitor / 否
HY-168768 FerroLOXIN-1 Inhibitor / 否
HY-173332 15-LOX-1 inhibitor 2 Inhibitor / 否
HY-N15453 Asperenone Inhibitor / 否
HY-N2056R 11-Keto-beta-boswellic acid (Standard) Inhibitor / 否
HY-RS16507 Lox Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22939 Lox Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W028263 6-Hydroxyflavanone Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lox NCBI NCBI:4015
Macaca fascicularis Lox NCBI NCBI:102132184
Rattus norvegicus Lox NCBI NCBI:24914
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