1. Gene
  2. C3 - complement C3 Gene

C3 - complement C3 Gene

种属: Rattus norvegicus

基因 ID: 24232 | 基因类型: protein coding

关于 C3

功能概要

Enables lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to steroid hormone. Located in extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); pneumocystosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Apr 2022]

C3 基因产物(1)

mRNA Protein Name
NM_016994.2 NP_058690.2 complement C3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipid binding IDA
IDA: 通过直接分析推断
11305612 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12871224 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in complement activation IDA
IDA: 通过直接分析推断
20712003 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18178156 RGD
involved in positive regulation of developmental growth IDA
IDA: 通过直接分析推断
20712003 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
12370124 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
11846090 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
11566438 RGD
involved in response to magnesium ion IEP
IEP: 通过表达模式推断
12759143 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
11566438 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
29695418 RGD
involved in tolerance induction IEP
IEP: 通过表达模式推断
16555329 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
20712003 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

complement C3

complement component 3

直系同源

种属 基因名 来源 基因 ID
Homo sapiens C3 NCBI NCBI:718
Canis familiaris C3 NCBI NCBI:476728
Macaca fascicularis C3 NCBI NCBI:102131458
Mus musculus C3 NCBI NCBI:12266
Susscrofa domestica C3 NCBI
Leporidae C3 NCBI
Macaca mulatta C3 NCBI NCBI:703613