2. Gene
  3. Bcr - BCR activator of RhoGEF and GTPase Gene

Bcr - BCR activator of RhoGEF and GTPase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 309696 | 基因类型: protein coding

关于 Bcr

功能概要

Enables enzyme binding activity. Involved in platelet-derived growth factor receptor signaling pathway and protein autophosphorylation. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Bcr 基因产物(2)

mRNA Protein Name
XM_039099171.1 XP_038955099.1 breakpoint cluster region protein isoform X1
XM_039099172.1 XP_038955100.1 breakpoint cluster region protein isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
10403766 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20962234 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
11560856 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
11560856 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20962234 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
20962234 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

breakpoint cluster region protein

BCR, RhoGEF and GTPase activating protein

breakpoint cluster region homolog

相关产品

Approval
生物活性分子 (17)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10181 Dasatinib 99.85% 是
HY-15463 Imatinib 99.95% 是
HY-10159 Nilotinib 99.94% 是
HY-50946 Imatinib Mesylate 99.98% 是
HY-104010 Asciminib Inhibitor 99.61% 是
HY-15666 Olverembatinib Inhibitor 99.47% 是
HY-10181A Dasatinib hydrochloride 99.67% 是
HY-10159A Nilotinib monohydrochloride monohydrate 99.91% 是
HY-129390 Orelabrutinib Inhibitor 99.97% 是
HY-13904 Flumatinib Inhibitor 99.94% 否
HY-15728 Radotinib 99.19% 是
HY-104010A Asciminib hydrochloride Inhibitor 99.84% 是
HY-10181B Dasatinib monohydrate 99.58% 是
HY-15666A Olverembatinib dimesylate Inhibitor 99.80% 是
HY-13905 Flumatinib mesylate Inhibitor 99.80% 否
HY-10159B Nilotinib hydrochloride / 否
HY-50946R Imatinib Mesylate (Standard) / 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-13024 Rebastinib 99.91% Phase 2
HY-50868 Bafetinib 99.18% Phase 2
HY-137460 Vodobatinib Inhibitor 98.09% Phase 2
HY-109010 Poseltinib Inhibitor 98.08% Phase 2
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
HY-120508 Pivanex 95.0% Phase 2
HY-15493 AN-019 Inhibitor / Phase 2
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-118084 LS-104 / Phase 1
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99761 Obexelimab 99.99% Phase 3
HY-P991086 MGD010 Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (125)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13520 Nocodazole 99.59% 否
HY-130604 DT2216 99.97% 否
HY-13264 Degrasyn 99.70% 否
HY-147308 Zelenirstat Inhibitor 99.76% 否
HY-125845 (S,R,S)-AHPC 99.13% 否
HY-11007 GNF-2 Inhibitor 99.82% 否
HY-15738 GNF-5 Inhibitor 99.95% 否
HY-10943 GNF-7 Inhibitor 99.70% 否
HY-125834 GMB-475 98.69% 否
HY-158145 DS55980254 Inhibitor 99.65% 否
HY-157562 DS68591889 99.18% 否
HY-152036A SIAIS100 TFA Degrader 99.75% 否
HY-128756 SIAIS178 Inhibitor 99.36% 否
HY-153415 PROTAC BCR-ABL Degrader-1 Degrader 98.73% 否
HY-10181S Dasatinib-d8 99.15% 否
HY-13943 CNX-774 Inhibitor 99.92% 否
HY-153357 NRX-0492 Degrader 98.16% 否
HY-147414 Vamotinib Inhibitor 99.89% 否
HY-10159S Nilotinib-d6 99.95% 否
HY-103274 PD180970 99.27% 否
HY-18010 PCI 29732 Inhibitor 99.86% 否
HY-136268 AQX-435 Activator 99.15% 否
HY-100338 CNX-500 Inhibitor 99.88% 否
HY-131669 Dasatinib metabolite M6 99.64% 否
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.05% 否
HY-15463S Imatinib-d8 99.88% 否
HY-107447 N-Deshydroxyethyl Dasatinib 98.58% 否
HY-103275 Adaphostin 99.02% 否
HY-15814 HG-7-85-01 99.94% 否
HY-15463S1 Imatinib-d4 99.86% 否
HY-157327 AKE-72 Inhibitor 98.29% 否
HY-101489A GZD856 (formic) 95.36% 否
HY-123450 S116836 99.60% 否
HY-145887 BCR-ABL1-IN-1 99.82% 否
HY-117718 AG957 Inhibitor 99.30% 否
HY-123159 AKI603 Inhibitor 98.03% 否
HY-133794 Dasatinib N-oxide 99.24% 否
HY-13904S Flumatinib-d3 Inhibitor 99.9% 否
HY-153008 BCR-ABL-IN-7 Inhibitor 99.66% 否
HY-156148 BCR-ABL-IN-8 Inhibitor / 否
HY-111872 SNIPER(ABL)-020 Inhibitor 99.79% 否
HY-108486 Herbimycin A Inhibitor 99% 否
HY-123390 DB07107 Inhibitor / 否
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor 99.17% 否
HY-15463S2 Imatinib-d3 hydrochloride 95.19% 否
HY-10159C Nilotinib hydrochloride dihydrate 99.89% 否
HY-10181S1 Dasatinib-d4 97.54% 否
HY-41940 Dasatinib intermediate-1 Control ≥98.0% 否
HY-108704 CT-721 Inhibitor / 否
HY-128607 Mcl1-IN-9 Inhibitor / 否
HY-136526 BCR-ABL-IN-3 Inhibitor / 否
HY-133794S Dasatinib N-oxide-d8 / 否
HY-101268 CHMFL-ABL-053 Inhibitor / 否
HY-10159S1 Nilotinib-13C,d3 / 否
HY-101763B (S,R,S)-AHPC dihydrochloride / 否
HY-10181G Dasatinib (GMP) / 否
HY-10212A BIIB021 mesylate / 否
HY-10364 AP24163 Inhibitor / 否
HY-119177 PD173956 Inhibitor / 否
HY-120036 Tyrphostin AG1112 Inhibitor / 否
HY-131275 Imatinib Impurity E 96.05% 否
HY-142922 BCR-ABL-IN-4 Inhibitor / 否
HY-147581 BTK-IN-11 Inhibitor / 否
HY-147584 BTK-IN-14 Inhibitor / 否
HY-150566 BCR-ABL-IN-5 Inhibitor / 否
HY-150569 BCR-ABL-IN-6 Inhibitor / 否
HY-150908 Brigatinib A / 否
HY-152036 SIAIS100 Degrader / 否
HY-153085 CD19 CAR circRNA / 否
HY-153582 ML 2-23 Degrader / 否
HY-15728S Radotinib-d6 / 否
HY-157389 AK-HW-90 Inhibitor / 否
HY-160478 GNF-6 Inhibitor / 否
HY-161323 FLT3-ITD/D835Y-IN-1 / 否
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / 否
HY-162257 BTK-IN-34 Inhibitor / 否
HY-162489 Tyrosine kinase-IN-8 Inhibitor / 否
HY-162698 JMF4073 Inhibitor / 否
HY-162952 cSRC/BCR-ABL1-IN-1 Inhibitor / 否
HY-168963 PROTAC BTK Degrader-13 / 否
HY-169230 BCR-ABL-IN-9 Inhibitor / 否
HY-169231 BCR-ABL-IN-10 Inhibitor / 否
HY-171184 EAPB0503 / 否
HY-172096 cSRC/BCR-ABL-IN-1 Inhibitor / 否
HY-176269 VS1150 / 否
HY-177273 Kinase modulator-1 Inhibitor / 否
HY-E70634 ABL1 E255K Recombinant Human Active Protein Kinase / 否
HY-E70635 ABL1 F317I Recombinant Human Active Protein Kinase / 否
HY-E70636 ABL1 G250E Recombinant Human Active Protein Kinase / 否
HY-E70637 ABL1 H396P Recombinant Human Active Protein Kinase / 否
HY-E70638 ABL1 M351T Recombinant Human Active Protein Kinase / 否
HY-E70639 ABL1 Q252H Recombinant Human Active Protein Kinase / 否
HY-E70640 ABL1 T315I Recombinant Human Active Protein Kinase / 否
HY-E70641 ABL1 Y253F Recombinant Human Active Protein Kinase / 否
HY-E70789 BCR-RET Recombinant Human Active Protein Kinase / 否
HY-E70808 BTK C481R Recombinant Human Active Protein Kinase / 否
HY-E70809 BTK V416L Recombinant Human Active Protein Kinase / 否
HY-RS01450 BCR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-123486 HS-438 / 否
HY-125090 PHA-680626 / 否
HY-132549S Nilotinib-d3 / 否
HY-15463S3 Imatinib-13C,d3 / 否
HY-160174 BCR-ABL kinase-IN-3 Inhibitor / 否
HY-160174A BCR-ABL kinase-IN-3 (dihydrocholide) Inhibitor / 否
HY-164393 ON044580 / 否
HY-164469 CHMFL-48 Inhibitor / 否
HY-169608 BCR-ABL-IN-11 Inhibitor / 否
HY-RS16598 Bcr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23032 Bcr Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-101489 GZD856 / 否
HY-110402 (S,R,S)-AHPC TFA / 否
HY-111871 SNIPER(ABL)-033 Inhibitor / 否
HY-111851 SNIPER(ABL)-049 Inhibitor / 否
HY-111854 SNIPER(ABL)-015 Inhibitor / 否
HY-111858 SNIPER(ABL)-050 Inhibitor / 否
HY-111859 SNIPER(ABL)-058 Inhibitor / 否
HY-111860 SNIPER(ABL)-013 Inhibitor / 否
HY-111861 SNIPER(ABL)-024 Inhibitor / 否
HY-111862 SNIPER(ABL)-044 Inhibitor / 否
HY-111873 SNIPER(ABL)-019 Inhibitor / 否
HY-100314 BCR-ABL-IN-1 Inhibitor / 否
HY-111863 SNIPER(ABL)-047 Inhibitor / 否
HY-111874 SNIPER(ABL)-039 Inhibitor / 否
HY-126143 CHMFL-ABL-039 Inhibitor / 否
HY-18819 BCR-ABL-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcr NCBI NCBI:613
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