TRPA1 - transient receptor potential cation channel subfamily A member 1 Gene

中文名称：瞬时受体电位阳离子通道亚家族 A 成员 1

种属: Homo sapiens

同用名: FEPS; p120; FEPS1; ANKTM1

基因 ID: 8989 | 基因类型: protein coding

关于 TRPA1

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:72,021,250-72,090,010 (from NCBI)

This gene has 6 transcripts (splice variants), 228 orthologues and is associated with 3 phenotypes. Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues.

功能概要

该基因编码的蛋白质结构与蛋白锚蛋白和跨膜蛋白高度相关。这种蛋白质的具体功能尚未确定；然而，研究表明该功能可能涉及信号转导和生长控制中的作用。[RefSeq 提供，2008 年 7 月]

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

TRPA1 基因产物(1)

mRNA	Protein	Name
NM_007332.3	NP_015628.2	transient receptor potential cation channel subfamily A member 1

TRPA1 蛋白结构

Ank_2

Ank

Ank_2

Ion_trans

0
200
400
600
800
1000
1119 a.a.

蛋白主名

其他名称

transient receptor potential cation channel subfamily A member 1

ankyrin-like with transmembrane domains 1

关联疾病

疾病名称

别名

Episodic Pain Syndrome, Familial, 1

FEPS1	Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement
Familial Episodic Pain Syndrome 1

Cramp-Fasciculation Syndrome

Cramp Fasciculation Syndrome

Foley-Denny-Brown Syndrome

Dentin Sensitivity

Sensitive Dentin

Familial Episodic Pain Syndrome

Feps

Photokeratitis

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Lidocaine Allergy

Lidoderm Allergy	Lignocaine Allergy
Xylocaine Allergy

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Alcoholic Neuropathy

Alcoholic Polyneuropathy	Alcohol-Related Polyneuropathy
Alcohol-Induced Polyneuropathy	Alcoholic Peripheral Neuropathy

Pain Agnosia

Analgesia

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Trigeminal Nerve Disease

Trigeminal Nerve Diseases	Disorders Of 5th Cranial Nerve
Disorders Of The Fifth Cranial Nerve

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Episodic Pain Syndrome, Familial, 3

FEPS3	Familial Episodic Pain Syndrome With Predominantly Lower Limb Involvement
Familial Episodic Pain Syndrome 3

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Cough Variant Asthma

Episodic Pain Syndrome, Familial, 2

FEPS2

Familial Episodic Pain Syndrome 2

Hyperhidrosis, Gustatory

Frey Syndrome	Gustatory Sweating
Auriculotemporal Nerve Syndrome	Gustatory Hyperhidrosis
Frey'S Syndrome	Sweating, Gustatory
HYPRG	Baillarger Syndrome
Hyperhidrosis Gustatory	Auriculotemporal Syndrome

Viral Laryngitis

Trigeminal Neuralgia

Tic Douloureux	Trifacial Neuralgia
Trifocal Neuralgia	Neuralgia Of The Fifth Cranial Nerve
Neuralgia Of 5th Cranial Nerve	Infraorbital Neuralgia

Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia

Spondyloepiphyseal Dysplasia, Maroteaux Type

Spondyloepiphyseal Dysplasia Maroteaux Type	Pseudo-Morquio Syndrome Type 2
Sed, Maroteaux Type	Brachyolmia Type 2
Pseudo-Morquio Syndrome, Type 2	Spondyloepiphyseal Dysplasia Of Maroteaux
Brachyolmia Maroteaux Type	SEDM
Sed Maroteaux Type	Dysplasia, Spondyloepiphyseal, Maroteaux Type

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction	Autonomic Nervous System Disorders
Autonomic Nervous System Disorder	Autonomic Nervous System Diseases
Abnormality Of The Autonomic Nervous System

Diabetic Neuropathy

Diabetic Neuropathies

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Neurodermatitis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Approval

生物活性分子 (1)

目录号	产品名	作用方式	纯度	是否罕见病
HY-N6810	Thymol		99.97%	是

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-115877	GDC-0334	Antagonist	/	Phase 1

Pre-clinical Phase

生物活性分子 (42)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100965	Diphenyleneiodonium chloride		99.39%	否
HY-15064	HC-030031	Inhibitor	99.97%	否
HY-101507	Pico145	Inhibitor	99.40%	否
HY-108463	A-967079	Antagonist	99.30%	否
HY-N6825	Hydroxy-α-sanshool	Agonist	99.57%	否
HY-18662	RQ-00203078	Antagonist	99.84%	否
HY-W014421	AP-18	Inhibitor	99.80%	否
HY-107436	LE135		99.03%	否
HY-111132	JT010	Agonist	99.90%	否
HY-108329	AM-0902	Antagonist	99.65%	否
HY-18779	PF-4840154	Agonist	99.50%	否
HY-120689	PF-04745637	Antagonist	99.97%	否
HY-W002116	Methyl syringate	Activator	99.95%	否
HY-N8264	Moringin	Agonist	99.95%	否
HY-101907	ASP7663	Agonist	99.16%	否
HY-135013	Umbellulone	Activator	99.00%	否
HY-N1500	Pulegone	Activator	98.80%	否
HY-121539	Supercinnamaldehyde	Activator	≥99.0%	否
HY-121636	Resolvin D2	Inhibitor	≥99.0%	否
HY-12809	Optovin	Activator	99.81%	否
HY-107535	AS1269574		99.84%	否
HY-N7117	1,4-Cineole	Activator	≥95.0%	否
HY-15065	Chembridge-5861528	Antagonist	99.76%	否
HY-N2318	Podocarpic acid	Agonist	99.78%	否
HY-148236	BAY-390	Inhibitor	98.01%	否
HY-134098	Diisopropyl adipate	Activator	99.90%	否
HY-156684	GDC-6599	Inhibitor	99.77%	否
HY-N7536	Voacangine		98.78%	否
HY-153711	TRPA1-IN-2	Inhibitor	99.82%	否
HY-W106234	4-(Phenyldiazenyl)benzoic acid	Agonist	98.81%	否
HY-142214	TRPA1-IN-1	Antagonist	/	否
HY-104061	AMG8788	Antagonist	/	否
HY-104062	AMG9678	Antagonist	/	否
HY-114524	(E)-4-Oxo-2-nonenal	Agonist	/	否
HY-121636S	Resolvin D2-d5	Inhibitor	/	否
HY-139904	TRPA1 Antagonist 3	Agonist	/	否
HY-N12605	hTRPA1-IN-1	Inhibitor	/	否
HY-N7965	Methyl kakuol	Agonist	/	否
HY-RS15103	TRPA1 Human Pre-designed siRNA Set A		/	否
HY-W002116S	Methyl syringate-d6		/	否
HY-N5142S1	α-Terpineol-d6	Inhibitor	/	否
HY-111494	TRPA1 Antagonist 1	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TRPA1	MGD	MGI:3522699
Canis familiaris	TRPA1	VGNC	VGNC:47865
Felis catus	TRPA1	VGNC	VGNC:67587
Macaca mulatta	TRPA1	VGNC	VGNC:78429
Bos taurus	TRPA1	VGNC	VGNC:36380
Rattus norvegicus	TRPA1	RGD	RGD:1303284
Others	TRPA1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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