2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection Immunology/Inflammation NF-κB MAPK/ERK Pathway Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. TRP Channel Bacterial Fungal NO Synthase COX NF-κB p38 MAPK Keap1-Nrf2 Heme Oxygenase (HO) PERK JNK Calcium Channel
  4. Pulegone

Pulegone  (Synonyms: 胡薄荷酮)

目录号: HY-N1500 纯度: 97.44%
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Pulegone 是一种广泛存在于多种植物精油中的单萜酮类化合物，也可作为鸟类驱避剂。Pulegone 具有抗炎、抗菌、抗真菌和抗痛觉过敏等多种活性。Pulegone 对沙门氏菌属细菌效果显著。

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Pulegone Chemical Structure

Pulegone Chemical Structure

CAS No. : 89-82-7

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规格 价格 是否有货 数量
500 mg ￥250
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1 g ￥400
In-stock
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Customer Review

Other Forms of Pulegone:

Pulegone 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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TRPC TRPM TRPV TRPA TRPML

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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HO-1 HO-2

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JNK1 JNK2 JNK3 JNK

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species[1][2][3][4][5].

体外研究
(In Vitro)

Pulegone (6.25-50 µg/mL; 20-26 h) 在 LPS (HY-D1056) 刺激的 RAW264.7 细胞中，可通过下调 iNOS、COX-2、NF-κB 和 MAPK 信号通路以及上调 Nrf-2/HO-1 来抑制炎性介质的表达[1]。
Pulegone (0.01-3 mM; 0-5 min) 可使鸡感觉神经元内的 Ca2+ 浓度升高[2]。
Pulegone (0.01-3 mM; 0-5 min) 在表达鸡 TRPM8、TRPA1、TRPV1 的 HEK293 细胞中，能激活 TRPM8 和 TRPA1，且高浓度 (1 mM 及以上) 抑制 TRPM8[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pulegone 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS (HY-D1056)-stimulated RAW264.7 cells.
Concentration: 6.25, 12.5, 25 and 50 µg/mL
Incubation Time: Pretreated with 2 h, then co-incubation for 18 h
Result: Inhibited the expression of iNOS, COX-2 and NF-κB.
Downregulated phosphorylation of ERK, JNK, and p38.
体内研究
(In Vivo)

Pulegone (100 mM; 足底注射; 单剂量) 在雏鸡中可引发疼痛相关行为，但该行为可被 TRPA1 拮抗剂抑制[2]。
Pulegone (10-150 mg/kg; 腹腔注射; 单剂量) 在大鼠炎症性疼痛模型中具有改善作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (300 g) treated Complete Freund's adjuvant (HY-153808)[3].
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Exerted an anti-hyperalgesic effect, increased the mechanical threshold, thermal heat threshold and decreased the thermal cold score at dose of 100 mg/kg.
Was devoid of in vivo locomotor side effects.
分子量

152.24

Formula

C10H16O
CAS 号
性状

液体（密度：0.937 g/cm3）

颜色

Colorless to light yellow

中文名称

胡薄荷酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Pulegone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pulegone89-82-7胡薄荷酮TRP ChannelBacterialFungalNO SynthaseCOXNF-κBp38 MAPKKeap1-Nrf2Heme Oxygenase (HO)PERKJNKCalcium ChannelTransient receptor potential channelsNitric oxide synthasesNOSCyclooxygenaseNuclear factor-κBNuclear factor-kappaBHeme OxygenaseProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasec-Jun N-terminal kinaseCa2+ channelsCa channelsinflammatory pain model RAW264.7 cellschicken sensory neuronsInhibitorinhibitorinhibit

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