1. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection Immunology/Inflammation NF-κB MAPK/ERK Pathway Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. TRP Channel Bacterial Fungal NO Synthase COX NF-κB p38 MAPK Keap1-Nrf2 Heme Oxygenase (HO) PERK JNK Calcium Channel
  3. Pulegone

Pulegone  (Synonyms: 胡薄荷酮)

目录号: HY-N1500 纯度: 97.44%
COA 产品使用指南 技术支持

Pulegone 是一种广泛存在于多种植物精油中的单萜酮类化合物,也可作为鸟类驱避剂。Pulegone 具有抗炎、抗菌、抗真菌和抗痛觉过敏等多种活性。Pulegone 对沙门氏菌属细菌效果显著。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Pulegone Chemical Structure

Pulegone Chemical Structure

CAS No. : 89-82-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
500 mg ¥250
In-stock
1 g ¥400
In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Pulegone:

MCE 顾客使用本产品发表的 1 篇科研文献

查看 TRP Channel 亚型特异性产品:

查看 NO Synthase 亚型特异性产品:

查看 COX 亚型特异性产品:

查看 NF-κB 亚型特异性产品:

查看 p38 MAPK 亚型特异性产品:

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看 JNK 亚型特异性产品:

查看 Calcium Channel 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species[1][2][3][4][5].

体外研究
(In Vitro)

Pulegone (6.25-50 µg/mL; 20-26 h) 在 LPS (HY-D1056) 刺激的 RAW264.7 细胞中,可通过下调 iNOS、COX-2、NF-κB 和 MAPK 信号通路以及上调 Nrf-2/HO-1 来抑制炎性介质的表达[1]
Pulegone (0.01-3 mM; 0-5 min) 可使鸡感觉神经元内的 Ca2+ 浓度升高[2]
Pulegone (0.01-3 mM; 0-5 min) 在表达鸡 TRPM8、TRPA1、TRPV1 的 HEK293 细胞中,能激活 TRPM8 和 TRPA1,且高浓度 (1 mM 及以上) 抑制 TRPM8[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: LPS (HY-D1056)-stimulated RAW264.7 cells.
Concentration: 6.25, 12.5, 25 and 50 µg/mL
Incubation Time: Pretreated with 2 h, then co-incubation for 18 h
Result: Inhibited the expression of iNOS, COX-2 and NF-κB.
Downregulated phosphorylation of ERK, JNK, and p38.
体内研究
(In Vivo)

Pulegone (100 mM; 足底注射; 单剂量) 在雏鸡中可引发疼痛相关行为,但该行为可被 TRPA1 拮抗剂抑制[2]
Pulegone (10-150 mg/kg; 腹腔注射; 单剂量) 在大鼠炎症性疼痛模型中具有改善作用[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (300 g) treated Complete Freund's adjuvant (HY-153808)[3].
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Exerted an anti-hyperalgesic effect, increased the mechanical threshold, thermal heat threshold and decreased the thermal cold score at dose of 100 mg/kg.
Was devoid of in vivo locomotor side effects.
分子量

152.24

Formula

C10H16O

CAS 号
性状

液体(密度:0.937 g/cm3

颜色

Colorless to light yellow

中文名称

胡薄荷酮

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Pulegone
目录号:
HY-N1500
需求量: