2. Anti-infection Stem Cell/Wnt JAK/STAT Signaling
  3. Bacterial STAT
  4. Golotimod hydrochloride

Golotimod hydrochloride  (Synonyms: SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride)

目录号: HY-14743B 纯度: 99.79%
COA 产品使用指南

摩尔计算器

Golotimod (SCV 07) hydrochloride 一种具有抗菌活性的免疫调节肽，可显著提高抗结核研究的功效，刺激胸腺和脾细胞增殖，并改善巨噬细胞功能。Golotimod hydrochloride 抑制 STAT3 信号传导并调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod hydrochloride 具有用于研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的潜力。

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Golotimod hydrochloride Chemical Structure

Golotimod hydrochloride Chemical Structure

CAS No. : 1029401-59-9

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥2850
In-stock
5 mg ￥650
In-stock
10 mg ￥1000
In-stock
50 mg ￥2500
In-stock
100 mg ￥3500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Golotimod hydrochloride:

Golotimod hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].

IC50 & Target[2]

STAT3

 

体内研究
(In Vivo)

Golotimod (SCV-07) hydrochloride (oral gavage or subcutaneous injection, 100 μg/kg, 5 days) reduces experimental recurrent genital HSV-2 disease by oral administration, more importantly, oral SCV07 after fasting shows a greater reduction in incidence and severity than SCV-07 without fasting in female hartley guinea pigs[1].
Golotimod (SCV-07) hydrochloride (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Hartley guinea pigs (250-300 g) infected HSV-2[1]
Dosage: 100 μg/kg
Administration: Oral gavage or subcutaneous injection; 5 days
Result: Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.
Animal Model: Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3]
Dosage: 10, 100 μg/kg or 1 mg/kg
Administration: Subcutaneous injection; once or twice a day from days 1 to 20
Result: Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg.
Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.
Clinical Trial
分子量

369.80

Formula

C16H20ClN3O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 150 mg/mL (405.62 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7042 mL 13.5208 mL 27.0416 mL
5 mM 0.5408 mL 2.7042 mL 5.4083 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 20 mg/mL (54.08 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Golotimod hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7042 mL 13.5208 mL 27.0416 mL 67.6041 mL
5 mM 0.5408 mL 2.7042 mL 5.4083 mL 13.5208 mL
10 mM 0.2704 mL 1.3521 mL 2.7042 mL 6.7604 mL
15 mM 0.1803 mL 0.9014 mL 1.8028 mL 4.5069 mL
20 mM 0.1352 mL 0.6760 mL 1.3521 mL 3.3802 mL
25 mM 0.1082 mL 0.5408 mL 1.0817 mL 2.7042 mL
30 mM 0.0901 mL 0.4507 mL 0.9014 mL 2.2535 mL
40 mM 0.0676 mL 0.3380 mL 0.6760 mL 1.6901 mL
50 mM 0.0541 mL 0.2704 mL 0.5408 mL 1.3521 mL
60 mM 0.0451 mL 0.2253 mL 0.4507 mL 1.1267 mL
80 mM 0.0338 mL 0.1690 mL 0.3380 mL 0.8451 mL
100 mM 0.0270 mL 0.1352 mL 0.2704 mL 0.6760 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Golotimod1029401-59-9SCV 07Gamma-D-glutamyl-L-tryptophanSCV07SCV-07BacterialSTATimmunomodulating peptideantimicrobialmacrophageoral mucositisHSV-2Inhibitorinhibitorinhibit

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