1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Guanfacine

Guanfacine  (Synonyms: 胍法辛)

目录号: HY-17416A
产品使用指南

Guanfacine 是一种去甲肾上腺素能 α2A 激动剂,具有口服活性,对 α2A 受体亚型具有高度选择性。Guanfacine 具有产生低血压和镇静作用。Guanfacine 可用于研究多种 PFC 认知障碍,包括妥瑞氏综合征和注意力缺陷多动障碍 (ADHD)。

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Guanfacine Chemical Structure

Guanfacine Chemical Structure

CAS No. : 29110-47-2

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规格 价格 是否有货 数量
5 mg ¥320
1 - 2 周
10 mg ¥512
1 - 2 周
25 mg ¥1000
1 - 2 周
50 mg ¥1600
1 - 2 周
100 mg ¥2300
1 - 2 周
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500 mg   询价  

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Other Forms of Guanfacine:

查看 Adrenergic Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3].

体外研究
(In Vitro)

Guanfacine increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level[1][3].
Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks[1][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Guanfacine enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task[1][3].
Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC[1][3].
Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing[1][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

246.09

Formula

C9H9Cl2N3O

CAS 号
中文名称

胍法辛;胍法新;氯苯乙胍

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-17416A
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