2. 天然产物
  3. 疾病研究领域 海洋天然产物 动物 其他类
  4. 癌症 海绵
  5. Halichondrin B

Halichondrin B 是从海绵 Halichondria okadai 中发现的。Halichondrin B 是一种非竞争性的 Vinca-alkaloid 与微管蛋白结合的抑制剂 (微管蛋白聚合 IC50 为 1.2-1.4 μM)，其具有抗肿瘤活性。

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Halichondrin B Chemical Structure

Halichondrin B Chemical Structure

CAS No. : 103614-76-2

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Halichondrin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC50 for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity[1].

体外研究
(In Vitro)

Halichondrin B (0.1-10 nM, 16 h) treatment inhibits the growth of L1210 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Halichondrin B 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: L1210 cells
Concentration: 0.1-10 nM
Incubation Time: 16 hours
Result: Inhibited L1210 cell with IC50 value of 0.3 nM.
分子量

1111.31

Formula

C60H86O19
CAS 号
结构分类
初始来源

Halichondria okadai Kadota
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halichondrin B103614-76-2OthersHalichondria okadaiVinca-alkaloid binding to tubulinanti-tumor activityL1210Inhibitorinhibitorinhibit

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