2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-49

HDAC-IN-49 是一种有效的非选择性 HDAC (HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC4 和 HDAC6 的 IC50 分别为 13 nM、14 nM、21 nM、1880 nM 和 10 nM 。HDAC-IN-49 表现出显着的抗白血病活性， 但对健康细胞具有低细胞毒性。

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HDAC-IN-49 Chemical Structure

HDAC-IN-49 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

HDAC-IN-49 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells[1].

IC50 & Target[1]

HDAC1

13 nM (IC50)

HDAC2

14 nM (IC50)

HDAC3

21 nM (IC50)

HDAC4

1880 nM (IC50)

HDAC6

10 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-49 (compound 10h) shows remarkable cytotoxic potential against different therapy-resistant leukemia cell lines, with IC50 values of 0.375 μM, 0.218 μM, and 0.285 μM for HAL01, HL60 and Jurkat cells, respectively. HDAC-IN-49 (compound 10h; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells[1].
HDAC-IN-49 (compound 10h; 6-36 μM; 24 h) shows a dose-dependent increase in the level of acetylation of α-tubulin and histone 3 (H3) in HL60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-49 相关抗体:

Apoptosis Analysis[1]

Cell Line: HL60 cells
Concentration: 1 μM and 5 μM
Incubation Time: 48 h
Result: Resulted in a significant apoptosis induction.

Western Blot Analysis[1]

Cell Line: HL60 cells
Concentration: 6 μM, 12 μM, 24 μM, 36 μM
Incubation Time: 24 h
Result: Increased in the level of acetylation of α-tubulin and histone 3 (H3).
分子量

478.52

Formula

C26H27FN4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-49 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-49HDACHistone deacetylasesHDAC inhibitorunselectiveacetylation of α-tubulinInhibitorinhibitorinhibit

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产品名称：
HDAC-IN-49
目录号：
HY-151897
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