2. Cell Cycle/DNA Damage Epigenetics Neuronal Signaling
  3. HDAC Monoamine Oxidase
  4. HDAC1/MAO-B-IN-1

HDAC1/MAO-B-IN-1 是一种有效的、选择性的、可穿过血脑屏障的 HDAC1/MAO-B 抑制剂，IC50 值分别为 21.4 nM 和 99.0 nM。HDAC1/MAO-B-IN-1 具有阿尔茨海默病研究的潜力。

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HDAC1/MAO-B-IN-1 Chemical Structure

HDAC1/MAO-B-IN-1 Chemical Structure

CAS No. : 2759855-37-1

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HDAC1/MAO-B-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1].

IC50 & Target[1]

HDAC1

21.4 nM (IC50)

MAO-B

99.0 nM (IC50)

体外研究
(In Vitro)

HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1].
HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC1/MAO-B-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 50 µM
Incubation Time: 24 h
Result: Displayed neuroprotective and inhibitory activity on ROS production.
体内研究
(In Vivo)

HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability[1].
HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, ICR male mice[1]
Dosage: 20 mg/kg
Administration: I.g.
Result: Exhibited favorable BBB (blood–brain barrier) permeability.
Animal Model: 20-25 g, ICR female mice[1]
Dosage: 15 mg/kg
Administration: I.p.; 15 consecutive days
Result: Improved the learning and memory abilities of the ICR mice.
分子量

328.79

Formula

C18H17ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC1/MAO-B-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC1/MAO-B-IN-12759855-37-1HDACMonoamine OxidaseHistone deacetylasesMAOCNSAlzheimer’s diseaseICR micePC12 cellsneuroprotectiveROScognitiveInhibitorinhibitorinhibit

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