2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC8-IN-4

HDAC8-IN-4 是 HDAC8 的选择性抑制剂。HDAC8-IN-4 抑制 HDAC8 和 HDAC3，IC50s 分别为 0.15 和 12 μM。

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HDAC8-IN-4 Chemical Structure

HDAC8-IN-4 Chemical Structure

CAS No. : 1600528-05-9

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HDAC8-IN-4 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC50s of 0.15 and 12 μM[1].

IC50 & Target[1]

HDAC8

0.15 μM (IC50)

HDAC3

12 μM (IC50)

体外研究
(In Vitro)

HDAC8-IN-4 (化合物 9) (1-100 μM，5-6 天) 抑制 HeLa 细胞中的 HDAC8 蛋白水平[1]。
HDAC8-IN-4 (约 0-50 μM，72 小时) 抑制 T 细胞淋巴瘤细胞 (Jurkat、HH、MT4、HUT78 细胞) 的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC8-IN-4 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Jurkat, HH, MT4, HUT78 cells
Concentration: 0-50 μM approximately
Incubation Time: 72 h
Result: Inhibited cell growth with IC50s of 2, 7.4, 5.8, 27 μM).

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0-40 μM
Incubation Time: 4 h
Result: Selectively inhibited HDAC8 over other HDACs in cells.
分子量

342.44

Formula

C17H14N2O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC8-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-41600528-05-9HDACHistone deacetylasesT-celllymphomaHeLaJurkatHHMT4HUT78Inhibitorinhibitorinhibit

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产品名称：
HDAC8-IN-4
目录号：
HY-153583
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