1. Stem Cell/Wnt Apoptosis
  2. Wnt β-catenin Apoptosis
  3. HLY78

HLY78 是 Lycorine (HY-N0288) 衍生物,是一种有效的 Wnt/β-catenin 信号通路的激活剂。HLY78 靶向于 Axin 的 DIX 结构域,促进 Axin-LRP6 的关联,从而促进 LRP6 磷酸化 (LRP6 phosphorylation) 和 Wnt 信号转导。HLY78 可用于蛛网膜下腔出血 (SAH) 的研究。

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HLY78 Chemical Structure

HLY78 Chemical Structure

CAS No. : 854847-61-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1320
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1 mg ¥545
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5 mg ¥1200
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10 mg ¥2000
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25 mg ¥4000
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50 mg ¥6400
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100 mg ¥9600
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500 mg   询价  

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Top Publications Citing Use of Products

    HLY78 purchased from MCE. Usage Cited in: Cancer Gene Ther. 2022 Dec 9.  [Abstract]

    Both HLY78 and BRD5631 significantly abrogate the effects of miR-219-5p on SKOV3 and SKOV3/DDP cell invasion (fig E) and migration (fig F).

    HLY78 purchased from MCE. Usage Cited in: Cancer Gene Ther. 2022 Dec 9.  [Abstract]

    Both HLY78 and BRD5631 significantly abrogate the effect of miR-219-5p on SKOV3 and SKOV3/DDP cell apoptosis.

    HLY78 purchased from MCE. Usage Cited in: Neurosci Bull. 2020 Oct;36(10):1171-1181.  [Abstract]

    Effects of HLY78 on neuronal apoptosis at 24 h after SAH. Representative Western blot bands of Bcl-2, Bax, and cleaved caspase.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3].

    IC50 & Target

    Wnt/β-catenin[1]

    体外研究
    (In Vitro)

    HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway[2].
    HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls[3].
    HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells[3].
    HLY78 significantly increases TNKS expression, which is ameliorated by Dihydroartemisinin (HY-N0176)[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    HLY78 (0-1.8 mg/kg, Intranasal injection, once) attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH (subarachnoid hemorrhage) in rats[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Sprague-Dawley rats (280-310 g, n=9/group, SAH model)[2]
    Dosage: 0, 0.2, 0.6, and 1.8 mg/kg
    Administration: Intranasal injection, once, at 1 h post-SAH (subarachnoid hemorrhage)
    Result: Significantly attenuated the short-term and long-term neurobehavioral deficits, as well as the neuronal apoptosis after SAH at 0.6 mg/kg. Successfully delivered into the brain via intranasal administration at 0.6 mg/kg and was sufficient to significantly increase the phosphorylation of LRP6. Reversed the changes of the Bcl-2, Bax, and cleaved caspase 3 levels.
    分子量

    267.32

    Formula

    C17H17NO2

    CAS 号
    性状

    固体

    颜色

    Off-white to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 26 mg/mL (97.26 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.7408 mL 18.7042 mL 37.4083 mL
    5 mM 0.7482 mL 3.7408 mL 7.4817 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 98.49%

    参考文献

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.7408 mL 18.7042 mL 37.4083 mL 93.5209 mL
    5 mM 0.7482 mL 3.7408 mL 7.4817 mL 18.7042 mL
    10 mM 0.3741 mL 1.8704 mL 3.7408 mL 9.3521 mL
    15 mM 0.2494 mL 1.2469 mL 2.4939 mL 6.2347 mL
    20 mM 0.1870 mL 0.9352 mL 1.8704 mL 4.6760 mL
    25 mM 0.1496 mL 0.7482 mL 1.4963 mL 3.7408 mL
    30 mM 0.1247 mL 0.6235 mL 1.2469 mL 3.1174 mL
    40 mM 0.0935 mL 0.4676 mL 0.9352 mL 2.3380 mL
    50 mM 0.0748 mL 0.3741 mL 0.7482 mL 1.8704 mL
    60 mM 0.0623 mL 0.3117 mL 0.6235 mL 1.5587 mL
    80 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1690 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    产品名称:
    HLY78
    目录号:
    HY-122816
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