1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Immunoproteasome inhibitor 1

Immunoproteasome inhibitor 1 

目录号: HY-144452 纯度: 99.59%
COA 产品使用指南

Immunoproteasome inhibitor 1 是一种有效的、可逆的、依时独立的免疫蛋白酶体 (immunoproteasome) 和蛋白酶体 (proteasome) 抑制剂 (β5c、β1i、β5i亚基的Kis分别为1.18、0.27、1.91 μM)。Immunoproteasome inhibitor 1 可用于研究一些肿瘤性疾病。

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Immunoproteasome inhibitor 1 Chemical Structure

Immunoproteasome inhibitor 1 Chemical Structure

CAS No. : 2755772-63-3

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5 mg ¥2900
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10 mg ¥4650
In-stock
25 mg ¥9200
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the research of certain neoplastic diseases[1].

IC50 & Target[1]

β5c submit

1.18 μM (Ki)

β1i submit

0.27 μM (Ki)

β2i submit

20 μM (Ki)

β5i submit

1.91 μM (Ki)

体外研究
(In Vitro)

Immunoproteasome inhibitor 1 (compound 9) (0-25 μM; 0-600 seconds; in Human 20S immunoproteasome and human 20S proteasome) has high binding affinity for the β1i subunit (0.27 µM) of immunoproteasome and proteasome, coupling with good inhibitory properties towards β5i and β5c subunits. And the results of against the β5i subunit shows that the inhibition is reversible, time-independent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

358.43

Formula

C20H26N2O4

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (278.99 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7899 mL 13.9497 mL 27.8995 mL
5 mM 0.5580 mL 2.7899 mL 5.5799 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Immunoproteasome inhibitor 1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7899 mL 13.9497 mL 27.8995 mL 69.7486 mL
5 mM 0.5580 mL 2.7899 mL 5.5799 mL 13.9497 mL
10 mM 0.2790 mL 1.3950 mL 2.7899 mL 6.9749 mL
15 mM 0.1860 mL 0.9300 mL 1.8600 mL 4.6499 mL
20 mM 0.1395 mL 0.6975 mL 1.3950 mL 3.4874 mL
25 mM 0.1116 mL 0.5580 mL 1.1160 mL 2.7899 mL
30 mM 0.0930 mL 0.4650 mL 0.9300 mL 2.3250 mL
40 mM 0.0697 mL 0.3487 mL 0.6975 mL 1.7437 mL
50 mM 0.0558 mL 0.2790 mL 0.5580 mL 1.3950 mL
60 mM 0.0465 mL 0.2325 mL 0.4650 mL 1.1625 mL
80 mM 0.0349 mL 0.1744 mL 0.3487 mL 0.8719 mL
100 mM 0.0279 mL 0.1395 mL 0.2790 mL 0.6975 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Immunoproteasome inhibitor 1
目录号:
HY-144452
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