1. Immunology/Inflammation
  2. Interleukin Related
  3. Keliximab

Keliximab  (Synonyms: SB-210396; IDEC CE9.1)

目录号: HY-P99680

Keliximab (SB-210396) 是一种嵌合的人/猕猴 IgG1CD4 单克隆抗体,对可溶性 CD4Kd 值为 1.0 nM。Keliximab 阻断 T 细胞增殖并抑制 IL-2 的产生。Keliximab 可用于癌症研究。

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Keliximab Chemical Structure

Keliximab Chemical Structure

CAS No. : 174722-30-6

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Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a Ki value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research[1][2].

(In Vitro)

Keliximab 与可溶性 CD4 结合的 Kd 值为 1.0 nM[2]
Keliximab (0.01-10 μg/mL;30 分钟) 剂量依赖性地结合 CD4+ 胸腺瘤细胞系 SupT1,ED50 为 0.2 μg/mL[1]
Keliximab (0-1000ng/mL) 在原发性人浆母细胞淋巴瘤 (PBLs) 中阻断 T 细胞增殖和 IL-2 产生,IC50 为 10-30 ng/mL[1]
Keliximab (1-1000 ng/mL;5 分钟) 剂量依赖性地介导细胞粘附,ED50 为 20 ng/mL[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

Keliximab (5-125 mg/kg;静脉注射,1 次) 减少 CD4+ T 细胞[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic mice bearing human CD4 molecules on their T cells[1]
Dosage: 5-125 mg/kg
Administration: Intravenous injection, 5-125 mg/kg, once
Result: Dose-dependently down-modulated CD4 and rapidly declined the number of circulating CD4+ T cells compared with clenoliximab.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.


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