2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. L-798106

L-798106  (Synonyms: CM9; GW671021)

目录号: HY-15274 纯度: 99.81%
COA 产品使用指南

摩尔计算器

L-798106 是强效且高度选择性的前列腺素类 EP3 受体拮抗剂 (Ki=0.3 nM)，它在 EP4，EP1 和 EP2 受体上也具有微摩尔活性，Ki 值分别为 916 nM，>5000 nM 和 >5000 nM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

L-798106 Chemical Structure

L-798106 Chemical Structure

CAS No. : 244101-02-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1841
In-stock
1 mg ￥709
In-stock
5 mg ￥1560
In-stock
10 mg ￥2496
In-stock
25 mg ￥5460
In-stock
50 mg ￥8775
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

L-798106 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has  micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM, respectively[1].

IC50 & Target

EP3

0.3 nM (IC50)

EP4

916 nM (IC50)

EP1

>5000 nM (IC50)

EP2

>5000 nM (IC50)

体外研究
(In Vitro)

L-798106 (200 nM) inhibits electrical field stimulation-induced contractile responses[2].
L-798106 (10 μM) inhibits electrical field stimulation-evoked ACh release[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-798106 相关抗体:

Cell Viability Assay[2]

Cell Line: Guinea-pig vas deferens
Concentration: 200 nM
Incubation Time:
Result: Showed an apparent pA2 of 7.48±0.25.

Cell Viability Assay[2]

Cell Line: Guinea-pig tracheal smooth muscle
Concentration: 10 μM
Incubation Time:
Result: Attenuated significantly the inhibitory effect of all agents tested (in % inhibition of EFS-induced release: 8-iso-PGE1 from 56.9 to 8.6; 8-iso-PGE2 from 51.6 to 9.2; PGE2 from 61.2 to 2.9; sulprostone from 55.9 to 18.8).
体内研究
(In Vivo)

L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 w) suppresses systemic insulin resistance and AT inflammation in db/db mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male db/db mice[3]
Dosage: 50 and 100 μg/kg
Administration: Oral gavage; 50 and 100 μg/kg; once daily; 8 weeks
Result: Suppressed the increased fasting blood glucose levels in the db/db mice.
Suppressed increased proinflammatory gene expressions in the adipocytes isolated from the epididymal AT of the db/db mice.
分子量

536.44

Formula

C27H22BrNO4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (18.64 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8641 mL 9.3207 mL 18.6414 mL
5 mM 0.3728 mL 1.8641 mL 3.7283 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.81%

COA (198 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

L-798106 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8641 mL 9.3207 mL 18.6414 mL 46.6035 mL
5 mM 0.3728 mL 1.8641 mL 3.7283 mL 9.3207 mL
10 mM 0.1864 mL 0.9321 mL 1.8641 mL 4.6604 mL
15 mM 0.1243 mL 0.6214 mL 1.2428 mL 3.1069 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-798106244101-02-8CM9 GW671021L798106L 798106CM 9CM-9GW671021GW 671021GW-671021Prostaglandin ReceptorGuinea-pig vas deferensGuinea-pig tracheal smooth muscleInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
L-798106
目录号：
HY-15274
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z