2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. l-Naproxen

l-Naproxen  (Synonyms: (R)-Naproxen)

目录号: HY-15031 纯度: 99.47%
COA 产品使用指南 技术支持

l-Naproxen ((R)-Naproxen) 是 (S)-Naproxen 的对映体异构体，l-Naproxen 可抑制 Cdc42 和 Rac1 (EC50 分别为 96 μM 和 212 μM)，并表现出抗肿瘤活性，l-Naproxen 是一类非甾体抗炎剂。

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l-Naproxen

l-Naproxen Chemical Structure

CAS No. : 23979-41-1

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Other Forms of l-Naproxen:

l-Naproxen 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID)[1][2][3].

体外研究
(In Vitro)

l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in HeLa cells[3].
l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3].
l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

l-Naproxen 相关抗体:

Cell Viability Assay[3]

Cell Line: HeLa cells
Concentration: 30-1000 μM
Incubation Time: 2 hour
Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively.

Cell Migration Assay [3]

Cell Line: OvCa429 and OvCa433 cells
Concentration: 0-300 μM
Incubation Time: 48 hour
Result: Inhibited migration of immortalized human ovarian cancer cells at 300 μM.

Western Blot Analysis[3]

Cell Line: OvCa433 cells
Concentration: 300 μM
Incubation Time: 48 hour
Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls.
分子量

230.26

Formula

C14H14O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

l-萘普生
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.63%

COA (284 KB)

产品使用指南 (1538 KB)
参考文献

l-Naproxen 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

l-Naproxen23979-41-1(R)-Naproxenl-萘普生Rasanti-tumor activityHeLaOvCa429OvCa433Inhibitorinhibitorinhibit

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目录号：
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