2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. LY5

LY5 是 STAT3 的抑制剂，IC50 值为 0.5 μM。LY5 诱导细胞凋亡并抑制 STAT3 磷酸化。LY5 具有体内抗肿瘤活性，可用于癌症的研究。

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LY5

LY5 Chemical Structure

CAS No. : 1436382-03-4

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规格 价格 是否有货 数量
1 mg ￥2400
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5 mg ￥6000
In-stock
10 mg 现货 询价
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100 mg   询价  

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Customer Review

LY5 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer[1].

IC50 & Target

IC50: 0.5 μM (STAT3)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SJRH30 IC50
0.55 μM
Compound: 8, LY5
Cytotoxicity against human Rh30 cells assessed as cell viability by MTT assay
Cytotoxicity against human Rh30 cells assessed as cell viability by MTT assay
[PMID: 23651330]
U2OS IC50
0.5 μM
Compound: 8, LY5
Cytotoxicity against human U2OS cells assessed as cell viability by MTT assay
Cytotoxicity against human U2OS cells assessed as cell viability by MTT assay
[PMID: 23651330]
体外研究
(In Vitro)

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50 values of 0.52, 0.55 and 1.39 μM, respectively[1].
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells[1].
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY5 相关抗体:

Western Blot Analysis[1]

Cell Line: RH30 and EW8 cell lines
Concentration: 0.25-1 μM
Incubation Time: 16 hours
Result: Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.
体内研究
(In Vivo)

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with MDA-MB-231 cancer cells injection[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result: Suppressed tumor growth and significantly reduced the tumor sizes.
分子量

329.33

Formula

C15H11N3O4S
CAS 号
性状

固体

颜色

Brown to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 6.25 mg/mL (18.98 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0365 mL 15.1823 mL 30.3647 mL
5 mM 0.6073 mL 3.0365 mL 6.0729 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

LY5 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0365 mL 15.1823 mL 30.3647 mL 75.9117 mL
5 mM 0.6073 mL 3.0365 mL 6.0729 mL 15.1823 mL
10 mM 0.3036 mL 1.5182 mL 3.0365 mL 7.5912 mL
15 mM 0.2024 mL 1.0122 mL 2.0243 mL 5.0608 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY51436382-03-4LY 5LY-5STATApoptosisapoptosisphosphorylationantitumorcancerU2OSRH30RD2IL-6miceInhibitorinhibitorinhibit

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