2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. Drug-Linker Conjugates for ADC EGFR STING
  4. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 

目录号: HY-148460
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摩尔计算器

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 是一种免疫刺激物抗体偶联物 (ISAC)，包含抗人表皮生长因子受体 2 (HER2) 抗体、STING 激动剂 (ADU- S100) 和一个连接子。Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 可用于癌症研究 (WO2018200812A1; example 5)。

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Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine Chemical Structure

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine Chemical Structure

CAS No. : 2249935-19-9

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Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1].

IC50 & Target[1]

HER2

 

体外研究
(In Vitro)

STING (stimulator of interferon genes) is an endoplasmic reticulum adaptor that facilitates innate immune signaling. It was reported that STING comprises four putative transmembrane regions, predominantly resides in the endoplasmic reticulum and is able to activate NF-kB, STAT6, and IRF3 transcription pathways to induce expression of type I interferon (e.g., IFN-a and IFN-β) and exert a potent anti-viral state following expression. In contrast, loss of STING rendered murine embryonic fibroblasts extremely susceptible to negative stranded virus infection, including vesicular stomatitis virus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 相关抗体:
Formula

C51H65N17O19P2S2.xC6H15N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S1002249935-19-9Drug-Linker Conjugates for ADCEGFRSTINGEpidermal growth factor receptorErbB-1HER1Stimulator of Interferon GenesTMEM173MITAERISMPYSHER2STING agonistADU- S100ADCISACInhibitorinhibitorinhibit

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Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine
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