2. Academic Validation
  3. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway

Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway

  • Cancer Lett. 2011 Dec 27;313(2):181-91. doi: 10.1016/j.canlet.2011.09.001.
Xinhua Pan 1,  Honghui Han,  Lei Wang,  Linli Yang,  Ruimei Li,  Zhenxi Li,  Junchen Liu,  Qufei Zhao,  Min Qian,  Mingyao Liu,  Bing Du
Affiliations

Affiliation

  • 1 The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
PMID: 21959111 DOI: 10.1016/j.canlet.2011.09.001
Abstract

Nitidine is a benzophenanthridine alkaloid, which has been shown to have anti-tumor properties. Here, we demonstrated that Nitidine Chloride (NC) could inhibit breast Cancer cells migration and invasion both in vitro and in vivo. Meanwhile, the protrusion formation and partial proteolytic activity of MMP-9 and MMP-2 were attenuated by NC in a dose-dependent manner in MDA-MB-231 cells. Furthermore, addition NC to cells significantly decreases PDGF induced phosphorylation of c-Src, FAK, MAPKs, activation of RhoA, Rac1 and AP-1 transcriptional activity. Taken together, our results indicate that NC could have potential as a novel anti-metastasis drug to breast Cancer.

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