2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ME-143

ME-143 是第二代肿瘤特异性 NADH 氧化酶 (NADH oxidase) 抑制剂。ME-143 抑制结直肠癌细胞中的 WNT/β-catenin 通路。ME-143 在体外和体内具有广泛的抗癌活性。

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ME-143 Chemical Structure

ME-143 Chemical Structure

CAS No. : 852536-39-1

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ME-143 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].

IC50 & Target

NADH oxidase[1]
体外研究
(In Vitro)

ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ME-143 相关抗体:

Cell Proliferation Assay[1]

Cell Line: RKO cell; DLD1 cell
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein.
体内研究
(In Vivo)

NADH氧化酶抑制剂

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

334.37

Formula

C21H18O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ME-143 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ME-143852536-39-1NV-143ME143ME 143NV143NV 143Endogenous Metabolitesecond-generationtumor-specificNADH oxidaseWNT/β-catenincancerInhibitorinhibitorinhibit

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