2. Metabolic Enzyme/Protease MAPK/ERK Pathway PI3K/Akt/mTOR NF-κB Immunology/Inflammation
  3. Phospholipase NADPH Oxidase p38 MAPK Akt NF-κB AP-1 Reactive Oxygen Species (ROS)
  4. MJ33

MJ-33 是一种竞争性的磷脂酶 A₂ (PLA₂) 抑制剂。MJ-33 通过阻断 Prdx6 的 PLA₂ 活性，从而抑制 NOX2 的激活，减少 ROS 的产生。MJ-33 能有效抑制酸性 PLA₂ (pH 4.0) 的活性，减少肺泡表面活性剂磷脂酰胆碱 (PC) 的降解，但对碱性 PLA₂ (pH 8.5) 无影响。MJ-33 显著减轻缺血再灌注 (I/R) 诱导的肺氧化损伤。MJ-33 通过抑制 MAPK、AKT、NF-κB 和 AP-1 信号通路，显著抑制前列腺癌细胞侵袭、迁移和黏附能力。MJ-33 可用于研究 ROS 相关疾病和前列腺癌。

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MJ33

MJ33 Chemical Structure

CAS No. : 137300-78-8

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MJ33 的其他形式现货产品:

Customer Review

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MJ33 相关抗体

Top Publications Citing Use of Products

查看 Phospholipase 亚型特异性产品:

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Phospholipase A PLD Phospholipase C

查看 NADPH Oxidase 亚型特异性产品:

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NOX1 NOX2 NOX4 NOX5 DUOX1

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 AP-1 亚型特异性产品:

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c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5). MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R). MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer[1][2][3].

分子量

492.55

Formula

C22H44F3O6P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MJ33 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MJ33137300-78-8MJ 33MJ-33PhospholipaseNADPH Oxidasep38 MAPKAktNF-κBAP-1Reactive Oxygen Species (ROS)NOXPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBActivator Protein 1phospholipase A2 inhibitorNADPH oxidase (NOX2)reactive oxygen species (ROS)peroxiredoxin 6 (Prdx6)lung ischemia-reperfusion injuryantioxidant therapymetastatic inhibitionInhibitorinhibitorinhibit

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