1. Immunology/Inflammation Apoptosis
  2. NOD-like Receptor (NLR) Pyroptosis Caspase Interleukin Related
  3. NLRP3-IN-81

NLRP3-IN-81 (N102) 是一种可穿透血脑屏障的抑制剂,可对抗 NLRP3 炎症小体依赖性细胞焦亡 (pyroptosis),其对 Nigericin (HY-127019) 诱导细胞焦亡的 EC50 为 0.029 μM。NLRP3-IN-81 可有效抑制 NLRP3 依赖性的 caspase-1 激活和 IL-1β 的释放。NLRP3-IN-81 可干扰 NLRP3 与衔接蛋白 ASC 的相互作用,并抑制 ASC 的寡聚化。NLRP3-IN-81 可用于细胞焦亡相关疾病的研究,例如炎症性肠病和 2 型糖尿病。

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NLRP3-IN-81 Chemical Structure

NLRP3-IN-81 Chemical Structure

CAS No. : 2922814-85-3

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  • 生物活性

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生物活性

NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes[1].

IC50 & Target

Caspase-1

 

IL-1β

 

NLRP3 inflammasome

0.029 μM (EC50)

分子量

372.36

Formula

C16H15F3N2O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NLRP3-IN-81
目录号:
HY-174312
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